Evidence map›Paper›PMID 35452803›Full record

ArticleNeuroImage2022

Open-source FlexNIRS: A low-cost, wireless and wearable cerebral health tracker.

Kuan-Cheng Wu, Davide Tamborini, Marco Renna, Adriano Peruch, Yujing Huang, Alyssa Martin, Kutlu Kaya, Zachary Starkweather, Alexander I Zavriyev, Stefan A Carp and 2 more

Registry-linked trialAbstract read
In one paragraph

Article in NeuroImage, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06994494 (Noninvasive Continuous BP Monitoring in Newborns Based on Pulsatile Signal Morphological Features Using NIRS), which is not on this map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06994494 recruitingnot on this mapstarted 2025, after this paper: background citation

Noninvasive Continuous BP Monitoring in Newborns Based on Pulsatile Signal Morphological Features Using NIRS

TypeobservationalSponsorMassachusetts General HospitalRan2025 to 2026Enrolled80ConditionsUnstable Blood Pressure, Hypotension
3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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  14. Resting-State Cerebral Hemodynamics is Associated With Problem Behaviors in Pediatric Sleep-Disordered Breathing.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kuan-Cheng WuAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA; Department of Biomedical Engineering, Boston University, 44 Cummington Mall, Boston, MA 02215, USA. Electronic address: kuan1031@bu.edu.
Davide TamboriniAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA.
Marco RennaAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA.
Adriano PeruchAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA.
Yujing HuangAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA.
Alyssa MartinAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA.
Kutlu KayaAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA.
Zachary StarkweatherAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA.
Alexander I ZavriyevAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA.
Stefan A CarpAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA.
David H SalatAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA.
Maria Angela FranceschiniAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA.

Funding

Time-Gated Diffuse Correlation Spectroscopy for functional imaging of the human brainU01EB028660 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI FRANCESCHINI, MARIA ANGELA · 2019 to 2023
$6.4M
DCS cerebral blood flow monitor for extreme low-birth-weight infantsR01HD091067 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI EL-DIB, MOHAMED, FRANCESCHINI, MARIA ANGELA · 2018 to 2022
$3.3M
NIRS-DCS for monitoring anesthesia and surgical manipulations of cerebral oxygen deliveryR01GM116177 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI FRANCESCHINI, MARIA ANGELA · 2016 to 2019
$1.6M
Development and validation of a law-cost cerebral oximeter for detection of cognitive impairment and Alzheimer's diseaseR21AG072481 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI FRANCESCHINI, MARIA ANGELA, SALAT, DAVID H · 2021 to 2021
$462k
NIA NIH HHS R21 AG072481NIBIB NIH HHS U01 EB028660NICHD NIH HHS R01 HD091067NIGMS NIH HHS R01 GM116177
6 · The paper itself

Abstract

Currently, there is great interest in making neuroimaging widely accessible and thus expanding the sampling population for better understanding and preventing diseases. The use of wearable health devices has skyrocketed in recent years, allowing continuous assessment of physiological parameters in patients and research cohorts. While most health wearables monitor the heart, lungs and skeletal muscles, devices targeting the brain are currently lacking. To promote brain health in the general population, we developed a novel, low-cost wireless cerebral oximeter called FlexNIRS. The device has 4 LEDs and 3 photodiode detectors arranged in a symmetric geometry, which allows for a self-calibrated multi-distance method to recover cerebral hemoglobin oxygenation (SO

Indexed as

Wearable Electronic DevicesWireless TechnologyBrainHeadHemoglobinsHumansOximetryPhantoms, ImagingHemoglobinsBluetooth low energyCerebral oximetryCommunity healthNIRSWearable device

Identifiers

PMID35452803
PMCPMC11262416

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.