Evidence map›Paper›PMID 35452600›Full record

ArticleCell metabolism2022

The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function.

Mathias Wenes, Alison Jaccard, Tania Wyss, Noelia Maldonado-Pérez, Shao Thing Teoh, Anouk Lepez, Fabrice Renaud, Fabien Franco, Patrice Waridel, Céline Yacoub Maroun and 9 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
117citing papers in PubMed, 1 pooled it
17.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

117 citing papers in PubMed, 1 synthesis or guideline pooled it, 182 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. DADA Enhances CD8Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review

57 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 4 countries.

Mathias WenesDepartment of Oncology, University of Lausanne, Épalinges, Switzerland. Electronic address: mathias.wenes@unige.ch.
Alison JaccardDepartment of Oncology, University of Lausanne, Épalinges, Switzerland; Ludwig Institute for Cancer Research, University of Lausanne, Épalinges, Switzerland.
Tania WyssDepartment of Oncology, University of Lausanne, Épalinges, Switzerland.
Noelia Maldonado-PérezGene and Cell Therapy Unit, Genomic Medicine Department, Pfizer-University of Granada-Junta de Andalucía, Centre for Genomics and Oncological Research (GENYO), Granada, Spain.
Shao Thing TeohDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA.
Anouk LepezBrain Tumor and Immune Cell Engineering Group, Faculty of Medicine, University of Geneva, Geneva, Switzerland; Center for Translational Research in Onco-Hematology, University of Geneva, Geneva, Switzerland; Swiss Cancer Center Léman, Geneva and Lausanne, Switzerland.
Fabrice RenaudDepartment of Oncology, University of Lausanne, Épalinges, Switzerland.
Fabien FrancoDepartment of Oncology, University of Lausanne, Épalinges, Switzerland; Ludwig Institute for Cancer Research, University of Lausanne, Épalinges, Switzerland.
Patrice WaridelProtein Analysis Facility, University of Lausanne, Lausanne, Switzerland.
Céline Yacoub MarounDepartment of Oncology, University of Lausanne, Épalinges, Switzerland.
Benjamin TschumiDepartment of Oncology, University of Lausanne, Épalinges, Switzerland.
Nina DumauthiozDepartment of Oncology, University of Lausanne, Épalinges, Switzerland.
Lianjun ZhangInstitute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China; Suzhou Institute of Systems Medicine, Suzhou 215123, China.
Alena DondaDepartment of Oncology, University of Lausanne, Épalinges, Switzerland.
Francisco MartínGene and Cell Therapy Unit, Genomic Medicine Department, Pfizer-University of Granada-Junta de Andalucía, Centre for Genomics and Oncological Research (GENYO), Granada, Spain.
Denis MiglioriniBrain Tumor and Immune Cell Engineering Group, Faculty of Medicine, University of Geneva, Geneva, Switzerland; Center for Translational Research in Onco-Hematology, University of Geneva, Geneva, Switzerland; Swiss Cancer Center Léman, Geneva and Lausanne, Switzerland; Department of Oncology, Geneva University Hospitals (HUG), Geneva, Switzerland.
Sophia Y LuntDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA; Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, MI, USA.
Ping-Chih HoDepartment of Oncology, University of Lausanne, Épalinges, Switzerland; Ludwig Institute for Cancer Research, University of Lausanne, Épalinges, Switzerland.
Pedro RomeroDepartment of Oncology, University of Lausanne, Épalinges, Switzerland. Electronic address: pedro.romero@unil.ch.
University of Lausanne · CHMichigan State University · USPfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research · ESSwiss Cancer Center Léman · CHLudwig Cancer Research · CHSuzhou Institute of Systems Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glycolysis, including both lactate fermentation and pyruvate oxidation, orchestrates CD8

Indexed as

Memory T CellsMonocarboxylic Acid TransportersLactatesMitochondriaMitochondrial Membrane Transport ProteinsPyruvic AcidLactatesMitochondrial Membrane Transport ProteinsMonocarboxylic Acid TransportersPyruvic Acidchimeric antigen receptor T cell therapyimmunometabolismmitochondrial pyruvate carrierT cell memorytumor-infiltrating lymphocyte metabolism

Identifiers

PMID35452600
PMCPMC9116152
OpenAlexW4224276457

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.