Evidence map›Paper›PMID 35452284›Full record

ArticleScience advances2022

The Australian dingo is an early offshoot of modern breed dogs.

Matt A Field, Sonu Yadav, Olga Dudchenko, Meera Esvaran, Benjamin D Rosen, Ksenia Skvortsova, Richard J Edwards, Jens Keilwagen, Blake J Cochran, Bikash Manandhar and 15 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 48 citations in OpenAlex.

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  6. Fine-scale recombination rates inferred using the canFam4 assembly are strongly correlated with previous maps of dog recombination.Mammalian genome : official journal of the International Mammalian Genome Society · 2025
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  13. Ancient genomes reveal over two thousand years of dingo population structure.Proceedings of the National Academy of Sciences of the United States of America · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 13 institutions in 6 countries.

Matt A FieldCentre for Tropical Bioinformatics and Molecular Biology, College of Public Health, Medical and Veterinary Sciences, James Cook University, Cairns, QLD 4878, Australia.ORCID 0000-0003-0788-6513
Sonu YadavSchool of Biotechnology and Biomolecular Sciences, UNSW Sydney, High St, Kensington, NSW 2052, Australia.ORCID 0000-0001-5521-2789
Olga DudchenkoThe Center for Genome Architecture, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0001-9163-9544
Meera EsvaranSchool of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0002-7886-1834
Benjamin D RosenAnimal Genomics and Improvement Laboratory, Agricultural Research Service, USDA, Beltsville, MD 20705, USA.ORCID 0000-0001-9395-8346
Ksenia SkvortsovaGarvan Institute of Medical Research, Victoria Street, Darlinghurst, NSW 2010, Australia.ORCID 0000-0003-1400-1998
Richard J EdwardsSchool of Biotechnology and Biomolecular Sciences, UNSW Sydney, High St, Kensington, NSW 2052, Australia.ORCID 0000-0002-3645-5539
Jens KeilwagenJulius Kühn-Institut, Erwin-Baur-Str. 27, 06484 Quedlinburg, Germany.ORCID 0000-0002-6792-7076
Blake J CochranSchool of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0002-9615-7939
Bikash ManandharSchool of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0003-1276-6954
Sonia BustamanteBioanalytical Mass Spectrometry Facility, Mark Wainwright Analytical Centre, University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0002-5411-2919
Jacob Agerbo RasmussenLaboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen 2100, Denmark.ORCID 0000-0002-7710-8912
Richard G MelvinDepartment of Biomedical Sciences, University of Minnesota Medical School, 1035 University Drive, Duluth, MN 55812, USA.ORCID 0000-0001-6428-6763
Barry ChernoffCollege of the Environment, Departments of Biology, and Earth and Environmental Sciences, Wesleyan University, Middletown, CT 06459, USA.ORCID 0000-0001-8439-4542
Arina OmerThe Center for Genome Architecture, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0003-1336-2505
Zane ColaricThe Center for Genome Architecture, Baylor College of Medicine, Houston, TX 77030, USA.
Eva K F ChanGarvan Institute of Medical Research, Victoria Street, Darlinghurst, NSW 2010, Australia.ORCID 0000-0002-6104-3763
Andre E MinocheGarvan Institute of Medical Research, Victoria Street, Darlinghurst, NSW 2010, Australia.ORCID 0000-0003-2757-4146
Timothy P L SmithU.S. Meat Animal Research Center, Agricultural Research Service, USDA, Rd 313, Clay Center, NE 68933, USA.ORCID 0000-0003-1611-6828
M Thomas P GilbertLaboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen 2100, Denmark.ORCID 0000-0002-5805-7195
Ozren BogdanovicGarvan Institute of Medical Research, Victoria Street, Darlinghurst, NSW 2010, Australia.ORCID 0000-0001-5680-0056
Robert A ZammitVineyard Veterinary Hospital, 703 Windsor Rd, Vineyard, NSW 2765, Australia.
Torsten ThomasSchool of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, NSW 2052, Australia.
Erez L AidenThe Center for Genome Architecture, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0003-0634-6486
J William O BallardDepartment of Environment and Genetics, SABE, La Trobe University, Melbourne, VIC 3086, Australia.ORCID 0000-0002-2358-6003
UNSW Sydney · AUGarvan Institute of Medical Research · AUBaylor College of Medicine · USUniversity of Copenhagen · DKAgricultural Research Service · USBroad Institute · USJulius Kühn-Institut · DENew South Wales Department of Health · AURoman L. Hruska U.S. Meat Animal Research Center · USThe University of Melbourne · AUThe University of Sydney · AUUniversity of Minnesota, Duluth · USWesleyan University · US

Funding

Center for Genome ImagingRM1HG011016 · NHGRI · HARVARD MEDICAL SCHOOL · PI WU, CHAO-TING · 2021 to 2025
$12.2M
GENOME WIDE MAPPING OF LOOPS USING IN SITU HI-CUM1HG009375 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI LIEBERMAN-AIDEN, EREZ · 2017 to 2021
$4.7M
Beyond Gene Dosage: Understanding Down Syndrome via 4D Genome OrganizationU01HL156059 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LI, WENBO · 2020 to 2024
$3.1M
Supplement - Beyond pairwise DNA contacts: exploring higher-order genome structure using proximity ligationU01HL130010 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI LIEBERMAN-AIDEN, EREZ · 2015 to 2019
$2.3M
NHGRI NIH HHS RM1 HG011016NHGRI NIH HHS UM1 HG009375NHLBI NIH HHS U01 HL130010NHLBI NIH HHS U01 HL156059
6 · The paper itself

Abstract

Dogs are uniquely associated with human dispersal and bring transformational insight into the domestication process. Dingoes represent an intriguing case within canine evolution being geographically isolated for thousands of years. Here, we present a high-quality de novo assembly of a pure dingo (CanFam_DDS). We identified large chromosomal differences relative to the current dog reference (CanFam3.1) and confirmed no expanded pancreatic amylase gene as found in breed dogs. Phylogenetic analyses using variant pairwise matrices show that the dingo is distinct from five breed dogs with 100% bootstrap support when using Greenland wolf as the outgroup. Functionally, we observe differences in methylation patterns between the dingo and German shepherd dog genomes and differences in serum biochemistry and microbiome makeup. Our results suggest that distinct demographic and environmental conditions have shaped the dingo genome. In contrast, artificial human selection has likely shaped the genomes of domestic breed dogs after divergence from the dingo.

Indexed as

CanidaeWolvesAnimalsAustraliaBreedingDogsPhylogeny

Identifiers

PMID35452284
PMCPMC9032958
OpenAlexW4224231125

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.