Evidence map›Paper›PMID 35452257›Full record

ArticleEnvironmental health perspectives2022

Prenatal Phthalate Exposure and Child Weight and Adiposity from

Kelly K Ferguson, Paige A Bommarito, Olufunmilayo Arogbokun, Emma M Rosen, Alexander P Keil, Shanshan Zhao, Emily S Barrett, Ruby H N Nguyen, Nicole R Bush, Leonardo Trasande and 3 more

Abstract read
In one paragraph

Article in Environmental health perspectives, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
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  5. Mycoestrogen Exposure during Pregnancy: Impact of theEnvironmental health perspectives · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kelly K FergusonEpidemiology Branch, National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, North Carolina, USA.
Paige A BommaritoEpidemiology Branch, National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, North Carolina, USA.
Olufunmilayo ArogbokunEpidemiology Branch, National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, North Carolina, USA.ORCID 0000-0002-4401-5381
Emma M RosenEpidemiology Branch, National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, North Carolina, USA.
Alexander P KeilEpidemiology Branch, National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, North Carolina, USA.ORCID 0000-0002-0955-6107
Shanshan ZhaoBiostatistics and Computational Biology Branch, NIEHS, NIH, DHHS, Research Triangle Park, North Carolina, USA.
Emily S BarrettDepartment of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, New Jersey, USA.
Ruby H N NguyenDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0002-6598-8457
Nicole R BushDepartment of Psychiatry Behavioral Sciences, University of California, San Francisco (UCSF), San Francisco, California, USA.
Leonardo TrasandeDepartment of Pediatrics, NYU Grossman School of Medicine, New York, New York, USA.
Thomas F McElrathDivision of Maternal-Fetal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Shanna H SwanDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Sheela SathyanarayanaDepartment of Pediatrics, Seattle Children's Research Institute, University of Washington, Seattle, Washington, USA.

Funding

Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI ROBERT John LAUMBACH · 1988 to 2026
$47.4M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A. Troester · 2001 to 2026
$36.3M
The NYU Children’s Health & Environment Study: an ECHO CohortUG3OD023305 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI TRASANDE, LEONARDO · 2016 to 2024
$26.5M
The Mount Sinai Transdisciplinary Center on Early Environmental ExposuresP30ES023515 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Robert O Wright · 2014 to 2026
$21.3M
TIDES III: Endocrine Disruption, Hormones, and Sex Differences in Adolescent Airway HealthR01ES025169 · NIEHS · SEATTLE CHILDREN'S HOSPITAL · PI Sheela Sathyanarayana · 2015 to 2026
$9.5M
The Infant Development and the Environmental Study (TIDES)R01ES016863 · NIEHS · UNIVERSITY OF ROCHESTER · PI SWAN, SHANNA H · 2009 to 2014
$4.0M
Phthalate and stressful life event exposures and pregnancy outcomes: The role of oxidative stressZIAES103313 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI FERGUSON, KELLY · 2016 to 2022
$1.9M
Intramural NIH HHS ZIA ES103313NIEHS NIH HHS P30 ES005022NIEHS NIH HHS P30 ES010126NIEHS NIH HHS P30 ES023515NIEHS NIH HHS R01 ES016863NIEHS NIH HHS R01 ES025169NIH HHS UG3 OD023305
6 · The paper itself

Abstract

backgroundPrenatal phthalate exposure has been associated with lower birth weight but also higher weight in childhood. Few studies have examined weight or adiposity from birth to childhood and thus cannot assess growth trajectories associated with exposure.

objectiveWe assessed associations between maternal phthalate exposures in pregnancy and child weight and adiposity measured prenatally through childhood (3-6 years of age).

methodsWithin The Infant Development and the Environment Study (TIDES), a prospective pregnancy cohort, we analyzed a panel of phthalate metabolites in urine collected at two visits from early and late gestation (

resultsFor weight, we observed inverse associations between several phthalate metabolites and birth weight DISCUSSION: We observed associations between prenatal exposure to phthalates and lower weight at birth but not at childhood follow-up visits. However, for adiposity, we observed an interesting pattern of association with low adiposity at delivery as well as high adiposity at 3-4 years of age. Although it is not clear from our results whether these associations occur within the same children, such a pattern of adiposity in early life has been linked to cardiometabolic disease in adulthood and deserves special attention as an outcome in the study of prenatal exposures in the developmental origins of health and disease. https://doi.org/10.1289/EHP10077.

Indexed as

Environmental PollutantsPhthalic AcidsPrenatal Exposure Delayed EffectsAdiposityAdultBirth WeightChildEnvironmental ExposureFemaleHumansInfantInfant, NewbornObesityPregnancyProspective StudiesEnvironmental Pollutantsphthalic acidPhthalic Acids

Identifiers

PMID35452257
PMCPMC9031798

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.