ReviewMagnetic resonance in medicine2022
Review and consensus recommendations on clinical APT-weighted imaging approaches at 3T: Application to brain tumors.
Open access · hybridAbstract readReviewConsensus Statement
In one paragraph
Review in Magnetic resonance in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 148 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
148citing papers in PubMed, 4 pooled it
28.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
148 citing papers in PubMed, 4 syntheses or guidelines pooled it, 209 citations in OpenAlex.
- Quantitative Consistency of Amide Proton Transfer-Weighted MRI for Brain Tumor Differentiation: Systematic Review of Clinical Evidence.Tomography (Ann Arbor, Mich.) · 2026Pooled it
- Performance of amide proton transfer imaging to differentiate true progression from therapy-related changes in gliomas and metastases.European radiology · 2025Pooled it
- Detection of breast cancer lesions using APT weighted MRI: a systematic review.Journal of translational medicine · 2025Pooled it
- Differentiation between glioma recurrence and treatment effects using amide proton transfer imaging: A mini-Bayesian bivariate meta-analysis.Frontiers in oncology · 2022Pooled it
- Amide proton transfer-weighted CEST MRI for radiotherapy target delineation of glioblastoma: a prospective pilot study.European radiology experimental · 2024Trial
- Multi-Contrast Human Brain CEST MRI at 11.7 T: First In Vivo Demonstration.Magnetic resonance in medicine · 2026Article
- Self-Derived Dynamic Field Map Estimation and Correction in CEST MRI.Magnetic resonance in medicine · 2026Article
- Assessing Microstructural and Molecular Brain Changes in Early Cognitive Decline Using Multiparametric 3T Magnetic Resonance Imaging.Neurology international · 2026Article
- Diagnostic Accuracy of APTw and NOEw MRI Metrics for IDH Mutation and 1p/19q Codeletion Prediction in Gliomas.NMR in biomedicine · 2026Article
- Quantitative magnetic resonance imaging for accurate delineation of radiotherapy: a narrative review.Translational cancer research · 2026Review
- Multi-molecular saturation-transfer MR fingerprinting for differentiating tumor progression from treatment-related change in post-treatment IDH-wildtype glioblastoma: a feasibility study.Journal of neuro-oncology · 2026Article
- Quantitative Guanidinium CEST-Based pH Mapping at 3 T in Healthy and Pathological Muscle.NMR in biomedicine · 2026Article
- 5T-Based Glutamate Chemical Exchange Saturation Transfer Imaging for Adult Diffuse Glioma Stratification.Journal of magnetic resonance imaging : JMRI · 2026Article
- Differentiation between glioblastomas and solid brain metastases using amide proton transfer-weighted (APTw) MRI with and without fluid suppression.Magma (New York, N.Y.) · 2026Article
- Deep-learning saturation transfer magnetic resonance fingerprinting (ST-MRF) in patients with Parkinson's disease.NeuroImage · 2026Article
- Molecular Imaging Tools for Improved Risk Stratification of Pediatric Neuroblastoma.Radiology. Imaging cancer · 2026Article
- Molecular-Structural MRI Mismatch for Preoperative Risk Stratification of Pediatric Neuroblastoma.Radiology. Imaging cancer · 2026Article
- Article
- APT MRI Signature for Risk Stratification of Pediatric Medulloblastoma.Chemical & biomedical imaging · 2026Article
- Exploring the role of advanced MRI in understanding glioblastoma biology: A scoping review protocol.MethodsX · 2026Article
88 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
36 authors at 20 institutions in 11 countries.
Jinyuan ZhouDivision of MR Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-6684-7920
Moritz ZaissMagnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany.
Linda KnutssonDivision of MR Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-4263-113X
Phillip Zhe SunYerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.ORCID 0000-0003-4872-1192
Sung Soo AhnDepartment of Radiology and Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, South Korea.
Silvio AimeMolecular Imaging Center, Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.
Peter BachertDepartment of Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany.
Jaishri O BlakeleyDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Kejia CaiDepartment of Radiology, University of Illinois at Chicago, Chicago, Illinois, USA.
Michael A ChappellMental Health and Clinical Neurosciences and Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, Nottingham, UK.
Min ChenDepartment of Radiology, Beijing Hospital, National Center of Gerontology, Beijing, China.
Daniel F GochbergVanderbilt University Institute of Imaging Science (VUIIS), Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Steffen GoerkeDepartment of Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany.ORCID 0000-0002-0684-2423
Hye-Young HeoDivision of MR Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-7297-2015
Shanshan JiangDivision of MR Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Tao JinDepartment of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0003-2912-3517
Seong-Gi KimCenter for Neuroscience Imaging Research, Institute for Basic Science and Department of Biomedical Engineering, Sungkyunkwan University, Suwon, South Korea.
John LaterraDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Daniel PaechDepartment of Radiology, German Cancer Research Center, Heidelberg, Germany.ORCID 0000-0001-5755-6833
Mark D PagelDepartment of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0002-8109-3995
Ji Eun ParkDepartment of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.
Ravinder ReddyCenter for Advance Metabolic Imaging in Precision Medicine, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Akihiko SakataDepartment of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Sabine Sartoretti-ScheferInstitute of Radiology, Kantonsspital Winterthur, Winterthur, Switzerland.
A Dean SherryAdvanced Imaging Research Center and Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Seth A SmithVanderbilt University Institute of Imaging Science (VUIIS), Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Greg J StaniszDepartment of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
Pia C SundgrenDepartment of Diagnostic Radiology/Clinical Sciences Lund, Lund University, Lund, Sweden.
Osamu TogaoDepartment of Molecular Imaging and Diagnosis, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Moriel VandsburgerDepartment of Bioengineering, U.C. Berkeley, Berkeley, California, USA.ORCID 0000-0003-4052-205X
Zhibo WenDepartment of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Yin WuPaul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China.ORCID 0000-0002-4323-5083
Yi ZhangKey Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, Zhejiang, China.ORCID 0000-0001-8738-1851
Wenzhen ZhuDepartment of Radiology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Zhongliang ZuVanderbilt University Institute of Imaging Science (VUIIS), Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0001-7361-7480
Peter C M van ZijlDivision of MR Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Johns Hopkins University · USGerman Cancer Research Center · DEKennedy Krieger Institute · USVanderbilt University · USBeijing Hospital · CNChinese Academy of Sciences · CNEmory University · USFriedrich-Alexander-Universität Erlangen-Nürnberg · DEInstitute for Basic Science · KRKantonsspital Winterthur · CHKyoto University · JPKyushu University · JPLund University · SEMinistry of Education · NZThe University of Texas at Dallas · USThe University of Texas MD Anderson Cancer Center · USTongji Hospital · CNUlsan College · KRUniversity of California, Berkeley · USUniversity of Illinois Chicago · US
Funding
Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0MTR&D 4: Algorithms for functional and anatomical brain analysisP41EB015909 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI VAN ZIJL, PETER CM · 2012 to 2020
$13.1MSleep and Circadian Dysfunction, Brain and Neurobehavioral Development in AutismP50HD103538 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI S. Ali Fatemi, Bradley L Schlaggar · 2020 to 2026
$9.9MTRD 4: Platforms for multi-modal and multi-scale imaging dataP41EB031771 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Hanzhang Lu, Peter CM Van Zijl · 2021 to 2026
$9.9MHigh Spatial and Temporal Resolution MRI Mapping of Oxygen Consumption in HumansP41EB029460 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI Ravinder Reddy · 2021 to 2026
$7.6MNovel Approaches for CEST Labeling, Detection, Quantification and TranslationR01EB015032 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI VAN ZIJL, PETER CM · 2011 to 2019
$3.9MDeveloping Protein-based MRI Biomarkers for Alzheimer's DiseaseR01AG069179 · NIA · JOHNS HOPKINS UNIVERSITY · PI ZHOU, JINYUAN · 2020 to 2024
$3.3MQuantitative CEST MRI for GBM Early Response Prediction and Biopsy GuidanceR37CA248077 · NCI · JOHNS HOPKINS UNIVERSITY · PI Shanshan Jiang · 2021 to 2026
$2.2MAmide Proton Transfer (APT) MRI of Brain Tumors at 3TR01CA228188 · NCI · JOHNS HOPKINS UNIVERSITY · PI ZHOU, JINYUAN · 2019 to 2022
$1.6MNCI NIH HHS R01 CA228188NCI NIH HHS R37 CA248077NIA NIH HHS R01 AG069179NIBIB NIH HHS P41 EB015909NIBIB NIH HHS P41 EB029460NIBIB NIH HHS P41 EB031771NIBIB NIH HHS R01 EB015032NICHD NIH HHS P50 HD103538NIH HHS P51 OD011132
Abstract
Amide proton transfer-weighted (APTw) MR imaging shows promise as a biomarker of brain tumor status. Currently used APTw MRI pulse sequences and protocols vary substantially among different institutes, and there are no agreed-on standards in the imaging community. Therefore, the results acquired from different research centers are difficult to compare, which hampers uniform clinical application and interpretation. This paper reviews current clinical APTw imaging approaches and provides a rationale for optimized APTw brain tumor imaging at 3 T, including specific recommendations for pulse sequences, acquisition protocols, and data processing methods. We expect that these consensus recommendations will become the first broadly accepted guidelines for APTw imaging of brain tumors on 3 T MRI systems from different vendors. This will allow more medical centers to use the same or comparable APTw MRI techniques for the detection, characterization, and monitoring of brain tumors, enabling multi-center trials in larger patient cohorts and, ultimately, routine clinical use.
Indexed as
Brain NeoplasmsAmidesDimapritHumansMagnetic Resonance ImagingProtonsAmidesAPTDimapritProtonsAPT-weighted imagingAPTw standardizationbrain tumorCEST imaging
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.