Evidence map›Paper›PMID 35451962›Full record

ArticleeLife2022

A tRNA processing enzyme is a key regulator of the mitochondrial unfolded protein response.

James P Held, Gaomin Feng, Benjamin R Saunders, Claudia V Pereira, Kristopher Burkewitz, Maulik R Patel

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

James P HeldDepartment of Biological Sciences, Vanderbilt University, Nashville, United States.ORCID https://orcid.org/0000-0003-4322-2108
Gaomin FengDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, United States.
Benjamin R SaundersDepartment of Biological Sciences, Vanderbilt University, Nashville, United States.
Claudia V PereiraDepartment of Biological Sciences, Vanderbilt University, Nashville, United States.
Kristopher BurkewitzDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, United States.
Maulik R PatelDepartment of Biological Sciences, Vanderbilt University, Nashville, United States.ORCID https://orcid.org/0000-0003-3749-0122
Vanderbilt University · US

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STACIE B DUSETZINA · 1995 to 2026
$172.8M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
Vanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ALVIN C POWERS · 2012 to 2026
$29.3M
Shop Module CoreP30EY008126 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI David J. Calkins · 1989 to 2026
$19.6M
TRAINING PROGRAM IN ENVIRONMENTAL TOXICOLOGYT32ES007028 · NIEHS · VANDERBILT UNIVERSITY · PI F PETER Guengerich, Fiona Edith Harrison · 1985 to 2026
$15.7M
Vanderbilt Mouse Metabolic Physiology CenterU24DK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2001 to 2015
$14.9M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Mechanisms of mutant mitochondrial genome modulationR35GM145378 · NIGMS · VANDERBILT UNIVERSITY · PI MAULIK R PATEL · 2022 to 2026
$2.4M
Targeting ER-mitochondrial calcium signaling to promote healthier agingR01AG073354 · NIA · VANDERBILT UNIVERSITY · PI Kristopher Burkewitz · 2022 to 2026
$1.6M
Regulation of mitochondrial heteroplasmy dynamicsR01GM123260 · NIGMS · VANDERBILT UNIVERSITY · PI PATEL, MAULIK R · 2017 to 2021
$1.5M
Targeting mechanisms of inter-organelle communication to promote healthy agingR00AG052666 · NIA · VANDERBILT UNIVERSITY · PI BURKEWITZ, KRISTOPHER · 2019 to 2021
$726k
NCI NIH HHS P30 CA068485NEI NIH HHS P30 EY008126NIA NIH HHS R00 AG052666NIA NIH HHS R01 AG073354NIDDK NIH HHS P30 DK020593NIDDK NIH HHS P30 DK058404NIDDK NIH HHS U24 DK059637NIEHS NIH HHS T32 ES007028NIGMS NIH HHS R01 GM123260NIGMS NIH HHS R35 GM145378NIH HHS P40 OD010440
6 · The paper itself

Abstract

The mitochondrial unfolded protein response (UPR

Indexed as

Caenorhabditis elegans ProteinsAnimalsCaenorhabditis elegansMitochondriaTranscription FactorsUnfolded Protein ResponseCaenorhabditis elegans ProteinsTranscription FactorsC. eleganscell biologyELAC2/HOE-1mitochondriamitochondrial unfolded protein responsetRNAs

Identifiers

PMID35451962
PMCPMC9064297
OpenAlexW4224290163

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.