ArticleeLife2022
Cerebellum encodes and influences the initiation, performance, and termination of discontinuous movements in mice.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Purkinje Cells in Crus I and II Encode the Visual Stimulus and the Impending Choice as Monkeys Learn a Reinforcement-Based Visuomotor Association Task.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Representations of Subsecond Duration-Based Timing by Complex Spike Synchrony in Cerebellar Purkinje Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Self-timed movement initiation requires rapid sequential coordination of circuits in prefrontal cortex and cerebellum.bioRxiv : the preprint server for biology · 2026Article
- Cerebellum violates Marr-Albus predictions to train synapses on long-term anticipatory goals.bioRxiv : the preprint server for biology · 2026Article
- A brain-wide, trial- and time-dependent deterministic drive synergizes with within-trial noise to time self-initiated actions.bioRxiv : the preprint server for biology · 2026Article
- A neural language for the cerebellum: control of behavior via competing populations of Purkinje cells.Journal of neurophysiology · 2026Review
- Effects of Short-Term Synaptic Plasticity in Feedforward Inhibitory Circuits on Cerebellar Responses to Repetitive Sensory Input.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Correlation between cerebellar lesion topography and differential diagnosis with clinical presentation in dogs.Journal of veterinary internal medicine · 2026Article
- Anatomical and functional examination of superior colliculus projections to the inferior olivary in mice.Brain structure & function · 2025Article
- Reward-driven cerebellar climbing fiber activity influences both neural and behavioral learning.Current biology : CB · 2025Article
- The First of Us:bioRxiv : the preprint server for biology · 2025Article
- Reward-driven cerebellar climbing fiber activity influences both neural and behavioral learning.bioRxiv : the preprint server for biology · 2025Article
- Article
- Neuronal responses in the human primary motor cortex coincide with the subjective onset of movement intention in brain-machine interface-mediated actions.PLoS biology · 2025Article
- Purkinje cells of the cerebellum control deceleration of tongue movements.PLoS biology · 2025Article
- Cerebellar control of targeted tongue movements.The Journal of physiology · 2025Article
- Control of tongue movements by the Purkinje cells of the cerebellum.bioRxiv : the preprint server for biology · 2025Article
- Cerebellar-driven cortical dynamics can enable task acquisition, switching and consolidation.Nature communications · 2024Article
- Cerebellar Purkinje Cells Control Posture in Larval Zebrafish (bioRxiv : the preprint server for biology · 2024Article
- Mutation in Prkra results in cerebellar abnormality and reduced eIF2α phosphorylation in a model of DYT-PRKRA.Disease models & mechanisms · 2024Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The cerebellum is hypothesized to represent timing information important for organizing salient motor events during periodically performed discontinuous movements. To provide functional evidence validating this idea, we measured and manipulated Purkinje cell (PC) activity in the lateral cerebellum of mice trained to volitionally perform periodic bouts of licking for regularly allocated water rewards. Overall, PC simple spiking modulated during task performance, mapping phasic tongue protrusions and retractions, as well as ramping prior to both lick-bout initiation and termination, two important motor events delimiting movement cycles. The ramping onset occurred earlier for the initiation of uncued exploratory licking that anticipated water availability relative to licking that was reactive to water allocation, suggesting that the cerebellum is engaged differently depending on the movement context. In a subpopulation of PCs, climbing-fiber-evoked responses also increased during lick-bout initiation, but not termination, highlighting differences in how cerebellar input pathways represent task-related information. Optogenetic perturbation of PC activity disrupted the behavior by degrading lick-bout rhythmicity in addition to initiating and terminating licking bouts confirming a causative role in movement organization. Together, these results substantiate that the cerebellum contributes to the initiation and timing of repeated motor actions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.