Evidence map›Paper›PMID 35451824›Full record

ArticleACS infectious diseases2022

Structure-Based Design of α-Substituted Mercaptoacetamides as Inhibitors of the Virulence Factor LasB from

Cansu Kaya, Isabell Walter, Alaa Alhayek, Roya Shafiei, Gwenaëlle Jézéquel, Anastasia Andreas, Jelena Konstantinović, Esther Schönauer, Asfandyar Sikandar, Jörg Haupenthal and 4 more

Abstract read
In one paragraph

Article in ACS infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Exploring the Role ofACS infectious diseases · 2026
    Article
  2. Molecules (Basel, Switzerland) · 2026
    Article
  3. Identification of novelRSC medicinal chemistry · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Mutation ofMicrobiology spectrum · 2024
    Article
  8. Dual inhibitors ofChemical science · 2024
    Article
  9. A Supramolecular Antibiotic Targeting Drug-ResistantACS applied materials & interfaces · 2024
    Article
  10. Evaluation of Expanded 2-Aminobenzothiazole Library for Inhibition ofbioRxiv : the preprint server for biology · 2024
    Article
  11. Article
  12. Article
  13. Review
  14. 30th Annual GPPharmaceuticals (Basel, Switzerland) · 2023
    Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Cansu KayaHelmholtz Institute for Pharmaceutical Research Saarland (HIPS)─Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbrücken, Germany.
Isabell WalterHelmholtz Institute for Pharmaceutical Research Saarland (HIPS)─Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbrücken, Germany.
Alaa AlhayekHelmholtz Institute for Pharmaceutical Research Saarland (HIPS)─Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbrücken, Germany.
Roya ShafieiHelmholtz Institute for Pharmaceutical Research Saarland (HIPS)─Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbrücken, Germany.ORCID 0000-0001-9783-595X
Gwenaëlle JézéquelHelmholtz Institute for Pharmaceutical Research Saarland (HIPS)─Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbrücken, Germany.ORCID 0000-0001-8945-8680
Anastasia AndreasHelmholtz Institute for Pharmaceutical Research Saarland (HIPS)─Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbrücken, Germany.
Jelena KonstantinovićHelmholtz Institute for Pharmaceutical Research Saarland (HIPS)─Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbrücken, Germany.
Esther SchönauerDepartment of Biosciences and Medical Biology, University of Salzburg, Hellbrunner Straße, 34, 5020 Salzburg, Austria.ORCID 0000-0002-2625-9446
Asfandyar SikandarHelmholtz Institute for Pharmaceutical Research Saarland (HIPS)─Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbrücken, Germany.
Jörg HaupenthalHelmholtz Institute for Pharmaceutical Research Saarland (HIPS)─Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbrücken, Germany.
Rolf MüllerHelmholtz Institute for Pharmaceutical Research Saarland (HIPS)─Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbrücken, Germany.ORCID 0000-0002-1042-5665
Hans BrandstetterDepartment of Biosciences and Medical Biology, University of Salzburg, Hellbrunner Straße, 34, 5020 Salzburg, Austria.
Rolf W HartmannHelmholtz Institute for Pharmaceutical Research Saarland (HIPS)─Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbrücken, Germany.ORCID 0000-0002-5871-5231
Anna K H HirschHelmholtz Institute for Pharmaceutical Research Saarland (HIPS)─Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbrücken, Germany.ORCID 0000-0001-8734-4663

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antivirulence therapy has become a widely applicable method for fighting infections caused by multidrug-resistant bacteria. Among the many virulence factors produced by the Gram-negative bacterium

Indexed as

Pseudomonas aeruginosaVirulence FactorsBacterial ProteinsMetalloendopeptidasesVirulenceBacterial ProteinsMetalloendopeptidasesVirulence Factorsantibiotic resistanceheterocyclesLasBmercaptoacetamidesstructure-based designvirulence factors

Identifiers

PMID35451824
PMCPMC9112332

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.