Evidence map›Paper›PMID 35451772›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2022

Genomic Prediction of Complex Traits, Principles, Overview of Factors Affecting the Reliability of Genomic Prediction, and Algebra of the Reliability.

Jean-Michel Elsen

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Jean-Michel ElsenGenPhySE, Université de Toulouse, INRAE, ENVT, Castanet Tolosan, France. jean-michel.elsen@inrae.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The quality of the predictions of genetic values based on the genotyping of neutral markers (GEBVs) is a key information to decide whether or not to implement genomic selection. This quality depends on the part of the genetic variability captured by the markers and on the precision of the estimate of their effects. Selection index theory provided the framework for evaluating the accuracy of GEBVs once the information had been gathered, with the genomic relationship matrix (GRM) playing a central role. When this accuracy must be known a priori, the theory of quantitative genetics gives clues to calculate the expectation of this GRM. This chapter makes a critical inventory of the methods developed to calculate these accuracies a posteriori and a priori. The most significant factors affecting this accuracy are described (size of the reference population, number of markers, linkage disequilibrium, heritability).

Indexed as

Models, GeneticMultifactorial InheritanceGenomeGenotypePhenotypePolymorphism, Single NucleotideReproducibility of ResultsAccuracy of predictionsEffective number of lociGenomic predictionGenomic relationships matrix

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.