ArticleInternational journal of computer assisted radiology and surgery2022
Investigating the effect of electrode orientation on irreversible electroporation with experiment and simulation.
Article in International journal of computer assisted radiology and surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Stereotactic two-needle irreversible electroporation of liver tumors near critical structures: a proof-of-concept study.European radiology experimental · 2026Article
- Round Well Inset for Uniform Electric Field Distribution in Electroporation Applications.Bioengineering (Basel, Switzerland) · 2025Article
- Computer modelling and vegetable bench test of a bipolar electrode array intended for use in high frequency irreversible electroporation treatment of skin cancer.Biomedical engineering letters · 2025Article
- Effects of key parameters on pulsed field ablation of atrial fibrillation: potato experiments.Frontiers in cardiovascular medicine · 2025Article
- In Vitro Assay Development to Study Pulse Field Ablation Outcome Using Solanum Tuberosum.International journal of molecular sciences · 2024Article
- Pulsed Field Ablation for Atrial Fibrillation: Mechanisms, Advantages, and Limitations.Reviews in cardiovascular medicine · 2024Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIn recent years, irreversible electroporation (IRE) has been developed to specifically destroy undesirable tissues as an alternative to surgical resection. In this treatment, placing multiple electrodes in parallel is required to create a uniform electric field distribution. The process of maintaining parallel electrodes is challenging, and the effect of the electrodes' orientation accuracy has not been investigated quantitatively. This study investigates the impact of the electrode orientation along with various electrode and pulse parameters on the outcomes of IRE.
methodsThe electrode configurations that were considered were parallel, forward, and sideward orientation. A numerical model was developed to study the effect of electrode orientation on the electric field distribution, which was validated experimentally on potato tubers as it has similar properties to biological tissue. In addition, a conductivity test was performed to evaluate the conductivity and electroporation threshold of the potatoes.
resultsThe developed numerical model was validated by comparing the electroporated volumes between potatoes from the experiment and simulation, which achieved a mean dice score of [Formula: see text]. The potato has an electrical conductivity of 0.044-0.454 S/m with an electroporation threshold of 375 V/cm. ANOVA test showed that the difference in the electroporated regions obtained between a parallel orientation and a 5[Formula: see text] forward and sideward orientation was not significant.
conclusionThis study showed that the developed numerical models were validated and able to predict the outcome of IRE on potatoes. In addition, a 5[Formula: see text] tolerance on the electrode orientation can be defined to obtain a similar response to the parallel orientation.
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