Evidence map›Paper›PMID 35451672›Full record

ArticleJournal of autism and developmental disorders2023

Sex Differences on the ADOS-2.

Hannah M Rea, Roald A Øien, Frederick Shic, Sara Jane Webb, Allison B Ratto

Abstract read
In one paragraph

Article in Journal of autism and developmental disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Gender Differences: Confirmatory Factor Analysis of the ADOS-II.Journal of autism and developmental disorders · 2026
    Article
  6. Article
  7. Article
  8. Characterizing the Relationship Among the Social Competence Elements in Autistic Adolescents.Autism research : official journal of the International Society for Autism Research · 2025
    Article
  9. Article
  10. Review
  11. Article
  12. "You should smile more": Population-level sex differences in smiling also exist in autistic people.Autism : the international journal of research and practice · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Melatonin AttenuatesInternational journal of molecular sciences · 2024
    Article
  17. Review
  18. Time is of the essence: Age at autism diagnosis, sex assigned at birth, and psychopathology.Autism : the international journal of research and practice · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hannah M ReaPsychiatry & Behavioral Science Department, University of Washington, Seattle, WA, 98195, USA.ORCID http://orcid.org/0000-0002-3786-9725
Roald A ØienUiT-The Arctic University of Norway, PB 6060, 9037, Tromsø, Norway.
Frederick ShicCenter On Child Health, Behavior & Development, Seattle Children's Research Institute, Seattle, WA, 98105, USA.
Sara Jane WebbPsychiatry & Behavioral Science Department, University of Washington, Seattle, WA, 98195, USA.
Allison B RattoChildren's National Medical Center, 15245 Shady Grove Road, Suite 350, Rockville, MD, 20850, USA. aratto@childrensnational.org.

Funding

Multimodal Developmental Neurogenetics of Females with ASDR01MH100028 · NIMH · YALE UNIVERSITY · PI Allison Elizabeth Jack, LAUREN KENWORTHY · 2012 to 2026
$37.8M
Mechanisms of Brain Dysmorphology in MN1 C-Terminal Truncation Syndrome, a Novel Intellectual Developmental Disability Disorder P50HD103524 · NICHD · UNIVERSITY OF WASHINGTON · PI DANIEL DOHERTY · 2020 to 2026
$9.9M
Research_ProjectU54HD090257 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI GUAY-WOODFORD, LISA MARIE · 2016 to 2020
$5.9M
Healthy Worker Effect, Occupational Exposure to PM and Cardiopulmonary MortalityR01OH010028 · OH · UNIVERSITY OF CALIFORNIA BERKELEY · PI EISEN, ELLEN AURA · 2012 to 2014
$869k
NICHD NIH HHS P50 HD103524NICHD NIH HHS U54 HD090257NIMH NIH HHS R01 MH100028NIOSH CDC HHS R01 OH010028
6 · The paper itself

Abstract

The sex difference in the prevalence of autism spectrum disorder (ASD) may be magnified by sex differences on diagnostic measures. The current study compared autistic males and females on items on the gold-standard diagnostic measure, the Autism Diagnostic Observation Schedule, Second Edition (ADOS-2). In a sample of 8-to-17-year old autistic individuals from research (n = 229) and clinical settings (n = 238), females were less likely to show atypicalities on most items related to social-communication behaviors and on total and subscale scores. When controlling for overall intensity of symptomatology, no sex differences survived statistical corrections. Diagnostic criteria and/or gold-standard assessments may be less sensitive to female presentations of ASD and/or autistic females may exhibit fewer or less intense behaviors characteristic of ASD.

Indexed as

Autism Spectrum DisorderAutistic DisorderAdolescentChildCommunicationFemaleHumansMaleSex CharacteristicsSocial BehaviorADOSAutismDiagnosisSex differences

Identifiers

PMID35451672
PMCPMC10074828

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.