Evidence map›Paper›PMID 35451620›Full record

ArticleVirchows Archiv : an international journal of pathology2022

Assessing the prognostic value of tumor-infiltrating CD57+ cells in advanced stage head and neck cancer using QuPath digital image analysis.

Emma J de Ruiter, Sangeeta K Bisheshar, Reinout H de Roest, Frederik W R Wesseling, Frank J P Hoebers, Mari F C M van den Hout, C René Leemans, Ruud H Brakenhoff, Remco de Bree, Chris H J Terhaard and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Digital pathology in tau research: A comparison of QuPath and HALO.Journal of neuropathology and experimental neurology · 2025
    Article
  3. Article
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Emma J de RuiterDepartment of Pathology, University Medical Center Utrecht, Heidelberglaan 100, 3584, CX, Utrecht, The Netherlands. e.j.deruiter-2@umcutrecht.nl.ORCID http://orcid.org/0000-0003-0369-8267
Sangeeta K BishesharDepartment of Pathology, University Medical Center Utrecht, Heidelberglaan 100, 3584, CX, Utrecht, The Netherlands.
Reinout H de RoestDepartment of Otolaryngology/Head and Neck Surgery, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam, The Netherlands.
Frederik W R WesselingDepartment of Radiation Oncology (MAASTRO), GROW - School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands.
Frank J P HoebersDepartment of Radiation Oncology (MAASTRO), GROW - School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands.
Mari F C M van den HoutDepartment of Pathology, Maastricht University Medical Center, Maastricht, The Netherlands.
C René LeemansDepartment of Otolaryngology/Head and Neck Surgery, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam, The Netherlands.
Ruud H BrakenhoffDepartment of Otolaryngology/Head and Neck Surgery, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam, The Netherlands.
Remco de BreeDepartment of Head and Neck Surgical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands.
Chris H J TerhaardDepartment of Radiotherapy, University Medical Center Utrecht, Utrecht, The Netherlands.
Stefan M WillemsDepartment of Pathology, University Medical Center Utrecht, Heidelberglaan 100, 3584, CX, Utrecht, The Netherlands.
Amsterdam University Medical Centers · NLMaastricht University Medical Centre · NLUniversity Medical Center Groningen · NLUniversity Medical Center Utrecht · NLHeidelberg University · DEMaastricht University · NL

Funding

KWF Kankerbestrijding A6C 7072
6 · The paper itself

Abstract

This study aimed to assess the prognostic value of intratumoral CD57+ cells in head and neck squamous cell carcinoma (HNSCC) and to examine the reproducibility of these analyses using QuPath. Pretreatment biopsies of 159 patients with HPV-negative, stage III/IV HNSCC treated with chemoradiotherapy were immunohistochemically stained for CD57. The number of CD57+ cells per mm

Indexed as

Carcinoma, Squamous CellHead and Neck NeoplasmsPapillomavirus InfectionsBiomarkers, TumorHumansLymphocytes, Tumor-InfiltratingPrognosisReproducibility of ResultsSquamous Cell Carcinoma of Head and NeckBiomarkers, TumorDigital pathologyHead and neck squamous cell carcinoma (HNSCC)NK cellsPrognostic biomarkersQuPathTumor-infiltrating lymphocytes (TILs)

Identifiers

PMID35451620
PMCPMC9343309
OpenAlexW4224289232

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.