Evidence map›Paper›PMID 35451555›Full record

ArticleAmerican journal of medical genetics. Part A2022

A genome-wide association study of obstructive heart defects among participants in the National Birth Defects Prevention Study.

Sara R Rashkin, Mario Cleves, Gary M Shaw, Wendy N Nembhard, Eirini Nestoridi, Mary M Jenkins, Paul A Romitti, Xiang-Yang Lou, Marilyn L Browne, Laura E Mitchell and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of medical genetics. Part A, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Considering the Genetic Architecture of Hypoplastic Left Heart Syndrome.Journal of cardiovascular development and disease · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 14 institutions in 1 country.

Sara R RashkinDepartment of Epidemiology and Biostatistics, University of California, San Francisco, California, USA.ORCID 0000-0001-5542-6891
Mario ClevesDepartment of Pediatrics, Morsani College of Medicine, University of South Florida, Health Informatics Institute, Tampa, Florida, USA.
Gary M ShawDepartment of Pediatrics, Stanford University, Stanford, California, USA.ORCID 0000-0001-7438-4914
Wendy N NembhardDepartment of Epidemiology and Arkansas Center for Birth Defects and Prevention, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.ORCID 0000-0002-8318-4049
Eirini NestoridiMassachusetts Center for Birth Defects Research and Prevention, Massachusetts Department of Public Health, Boston, Massachusetts, USA.
Mary M JenkinsNational Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Paul A RomittiDepartment of Epidemiology, University of Iowa, Iowa City, Iowa, USA.
Xiang-Yang LouDepartment of Biostatistics, College of Public Health and Health Professions & College of Medicine, University of Florida, Gainesville, Florida, USA.
Marilyn L BrowneBirth Defects Research Section, New York State Department of Health, Albany, New York, USA.
Laura E MitchellDepartment of Epidemiology, Human Genetics, and Environmental Sciences, UTHealth School of Public Health, Houston, Texas, USA.
Andrew F OlshanDepartment of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA.
Kevin LomanginoKaufman Wills Fusting & Company, Baltimore, Maryland, USA.
Sudeepa BhattacharyyaBioinformatics and Data Science at University of Arkansas, Little Rock, Arkansas, USA.
John S WitteDepartment of Epidemiology and Biostatistics, University of California, San Francisco, California, USA.ORCID 0000-0003-0146-1434
Charlotte A HobbsRady Children's Institute for Genomic Medicine, San Diego, California, USA.
National Birth Defects Prevention Study
University of California, San Francisco · USCenters for Disease Control and Prevention · USChildren’s Institute · USEwing Marion Kauffman Foundation · USMassachusetts Department of Public Health · USNew York State Department of Health · USStanford University · USUniversity of Arkansas at Little Rock · USUniversity of Arkansas for Medical Sciences · USUniversity of Florida Health · USUniversity of Iowa · USUniversity of North Carolina at Chapel Hill · USUniversity of South Florida · USUniversity of Texas Health Science Center at Dallas · US

Funding

Genomic/Epigenomic Factors and Non-Syndromic Congenital Heart Defect Risk R01HD039054 · NICHD · ARKANSAS CHILDREN'S HOSPITAL RES INST · PI HOBBS, CHARLOTTE A · 2000 to 2016
$13.6M
Training in Molecular& Genetic Epidemiology of CancerR25CA112355 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WITTE, JOHN S. · 2005 to 2018
$6.5M
BD-STEPS II (Birth Defects Study To Evaluate Pregnancy exposures) - Core (Component A) & Steps Stillbirth (Component B)U01DD001224 · DD · MASSACHUSETTS STATE DEPT OF PUB HEALTH · PI MITCHELL, ALLEN A, YAZDY, MAHSA M · 2018 to 2022
$6.5M
Centers for Birth Defects Research and Prevention (CBDRPs)U01DD000491 · DD · ARKANSAS CHILDREN'S HOSPITAL RES INST · PI HOBBS, CHARLOTTE A · 2009 to 2013
$4.3M
Data Coordinating and Operations Center (DCOC) for the IDeA States Pediatric Clinical Trials NetworkU24HD090912 · NICHD · UNIV OF ARKANSAS FOR MED SCIS · PI HOBBS, CHARLOTTE A, LEE, JEANNETTE Y. · 2016 to 2016
$157k
EPA EP-D-18-001HSRD VA CDP 13-003NCBDD CDC HHS U01 DD000491NCBDD CDC HHS U01 DD001224NCBDD CDC HHS U01 DD001226NCBDD CDC HHS U01 DD001227NCI NIH HHS R25 CA112355NICHD NIH HHS R01 HD039054NICHD NIH HHS U24 HD090912
6 · The paper itself

Abstract

Obstructive heart defects (OHDs) share common structural lesions in arteries and cardiac valves, accounting for ~25% of all congenital heart defects. OHDs are highly heritable, resulting from interplay among maternal exposures, genetic susceptibilities, and epigenetic phenomena. A genome-wide association study was conducted in National Birth Defects Prevention Study participants (N

Indexed as

Genome-Wide Association StudyHeart Defects, CongenitalCase-Control StudiesFemaleGenetic Predisposition to DiseaseHumansInfantPolymorphism, Single NucleotideCAPN11congenital heart defectsGWASNational Birth Defects Prevention Studyobstructive heart defectsSLC44A2

Identifiers

PMID35451555
PMCPMC9283270
OpenAlexW4224230690

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.