Evidence map›Paper›PMID 35451518›Full record

ArticleClinical cardiology2022

Accuracy of echocardiographic estimations of right heart pressures in adult heart transplant recipients.

Aadhavi Sridharan, Monica M Dehn, Craig Cooper, Vidya S Madineedi, Linda J Ordway, David DeNofrio, Ayan R Patel

Open access · goldAbstract read
In one paragraph

Article in Clinical cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Elevated filling pressures are associated with poor long-term graft survival after pediatric heart transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Response to letter to the editor.Clinical cardiology · 2022
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Aadhavi SridharanCardiovascular Imaging and Hemodynamic Laboratory, Tufts Medical Center, Boston, Massachusetts, USA.ORCID http://orcid.org/0000-0003-1834-8147
Monica M DehnCardiovascular Imaging and Hemodynamic Laboratory, Tufts Medical Center, Boston, Massachusetts, USA.
Craig CooperCardiovascular Imaging and Hemodynamic Laboratory, Tufts Medical Center, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0003-0908-8216
Vidya S MadineediCardiovascular Imaging and Hemodynamic Laboratory, Tufts Medical Center, Boston, Massachusetts, USA.
Linda J OrdwayHeart Failure and Cardiac Transplant Program, Tufts Medical Center, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0001-6874-5840
David DeNofrioHeart Failure and Cardiac Transplant Program, Tufts Medical Center, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-5698-5318
Ayan R PatelCardiovascular Imaging and Hemodynamic Laboratory, Tufts Medical Center, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0003-1984-1400
Tufts University · USTufts Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAccurate assessment of right atrial pressure (RAP) and pulmonary artery systolic pressure (PASP) is critical in the management of heart transplant recipients. The accuracy of echocardiography in estimating these pressures has been debated.

objectiveTo assess the correlation and agreement between echocardiographic estimations of right heart pressures with those of respective invasive hemodynamic measurements by right heart catheterization (RHC) in adult heart transplant recipients.

methodsThis is a prospective evaluation of 84 unique measurements from heart transplant recipients who underwent RHC followed by standard echocardiographic evaluation within 159 ± 64 min with no intervening medication changes. The relationship between noninvasive pressure estimations and invasive hemodynamic measurements was examined.

resultsMean RAP was 7 ± 5 mmHg and mean PASP was 33 ± 8 mmHg by RHC. There was no significant correlation between echocardiographic estimation of RAP and invasive RAP (Spearman's rho = -0.05, p = .7), and no significant agreement between these two variables (weighted kappa = -0.1). There was a modest correlation between echocardiographic estimation of PASP and invasive PASP (r = .39, p = .002). Bland-Altman analysis showed a mean bias of 2.1 ± 9 mmHg (limits of agreement = -15 to 20 mmHg).

conclusionIn heart transplant recipients, there is no significant correlation or agreement between echocardiographic RAP estimation and invasively determined RAP. Noninvasive PASP estimation correlates significantly but modestly with invasively measured PASP. Further refinement of echocardiographic methods for assessment of RAP is warranted in this unique patient population.

Indexed as

Heart TransplantationPulmonary ArteryAdultCardiac CatheterizationEchocardiographyEchocardiography, DopplerHumansechocardiographyheart transplant recipientspulmonary artery systolic pressureright atrial pressure

Identifiers

PMID35451518
PMCPMC9286333
OpenAlexW4224227878

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.