ReviewEmerging infectious diseases2022
Invasive Group A Streptococcus Outbreaks Associated with Home Healthcare, England, 2018-2019.
Review in Emerging infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Evaluating the use of whole-genome sequencing and SangerJournal of medical microbiology · 2026Article
- Cross-sectional hospital-based investigation on clinical characteristics of pediatric Group A Streptococcus isolates in a Beijing hospital from 2014 to 2023.Annals of clinical microbiology and antimicrobials · 2026Article
- Control of an outbreak of invasive Group AEpidemiology and infection · 2025Article
- Increasing incidence of invasive group A streptococcal (iGAS) outbreaks in England 2015-2019.Epidemiology and infection · 2025Article
- Invasive group A Streptococcus infection (Streptococcus pyogenes): Current situation in Spain.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2024Article
- Changes in Group A Streptococcus emm Types Associated with Invasive Infections in Adults, Spain, 2023.Emerging infectious diseases · 2023Article
- Pathogenesis, epidemiology and control of Group A Streptococcus infection.Nature reviews. Microbiology · 2023Review
- Textiles as fomites in the healthcare system.Applied microbiology and biotechnology · 2023Review
- Cluster detection with random neighbourhood covering: Application to invasive Group A Streptococcal disease.PLoS computational biology · 2022Article
- Management of an outbreak of invasive group AWestern Pacific surveillance and response journal : WPSARArticle
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Healthcare-associated invasive group A Streptococcus (iGAS) outbreaks are common worldwide, but only England has reported outbreaks associated with home healthcare (HHC). We describe 10 outbreaks during 2018-2019 in England. A total of 96 iGAS cases (range 2-39 per outbreak) and 28 deaths (case-fatality rate 29%) occurred. Outbreak duration ranged from 3-517 days; median time between sequential cases was 20.5 days (range 1-225 days). Outbreak identification was difficult, but emm typing and whole-genome sequencing improved detection. Network analyses indicated multiple potential transmission routes. Screening of 366 HHC workers from 9 outbreaks identified group A Streptococcus carriage in just 1 worker. Outbreak control required multiple interventions, including improved infection control, equipment decontamination, and antimicrobial prophylaxis for staff. Transmission routes and effective interventions are not yet clear, and iGAS outbreaks likely are underrecognized. To improve patient safety and reduce deaths, public health agencies should be aware of HHC-associated iGAS.
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Registered trials
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