ArticleBrain and behavior2022
The understanding of Parkinson's disease through genetics and new therapies.
Article in Brain and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Epidemiology and etiology of brain cancer in Africa: A systematic review.Brain and behavior · 2023Pooled it
- Two-Dimensional Sagittal-Plane Gait Evaluation and Similarity Analysis in Parkinson's Disease Under ON and OFF Conditions: A Pilot Study.Brain sciences · 2026Article
- History, Challenges, and Perspectives of CNS-Targeted Transdermal Formulations.Current pharmaceutical design · 2026Review
- Affective and chronic fatigue symptoms are associated with serum neuronal damage markers in Parkinson's disease.Scientific reports · 2025Article
- Digital health technology for Parkinson's disease with comprehensive monitoring and artificial intelligence-enabled haptic biofeedback for bulbar dysfunction.Journal of Parkinson's disease · 2025Article
- The Prevalence of Depressive Symptoms in Patients with Idiopathic Parkinson's Disease: Cross-Sectional Study from Somalia.International journal of general medicine · 2024Article
- Exploring the landscape of autism in Africa: challenges in diagnosis, support, and resources - a short communication.Annals of medicine and surgery (2012) · 2023Article
- Dissecting the Relationship Between Neuropsychiatric and Neurodegenerative Disorders.Molecular neurobiology · 2023Review
- Prevalence and Influencing Factors of Depression in Patients with Parkinson's Disease.Alpha psychiatry · 2023Article
- Recent advances in novel mutation genes of Parkinson's disease.Journal of neurology · 2023Review
- Stem Cell Therapies in Movement Disorders: Lessons from Clinical Trials.Biomedicines · 2023Review
- Potential role of N6-methyladenosine modification in the development of Parkinson's disease.Frontiers in cell and developmental biology · 2023Review
- Poliovirus returns to the UK after nearly 40 years: current efforts and future recommendations.Postgraduate medical journal · 2022Article
- Yellow fever outbreak in Kenya: A review.Annals of medicine and surgery (2012) · 2022Review
- A short communication of Nipah virus outbreak in India: An urgent rising concern.Annals of medicine and surgery (2012) · 2022Article
- Polio returns to the USA: An epidemiological alert.Annals of medicine and surgery (2012) · 2022Article
- Measles outbreak in Zimbabwe: An urgent rising concern.Annals of medicine and surgery (2012) · 2022Article
- Hepatitis A virus outbreak in Lebanon: Is it a matter of concern?Annals of medicine and surgery (2012) · 2022Article
- A review of stem cell therapy: An emerging treatment for dementia in Alzheimer's and Parkinson's disease.Brain and behavior · 2022Review
- Anthrax outbreak amidst the COVID-19 pandemic in Africa: Challenges and possible solutions.Annals of medicine and surgery (2012) · 2022Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionParkinson's disease is one of the progressive neurodegenerative diseases from which people suffer for years. The mechanism of this disease is associated with a decrease in the number of dopaminergic neurons in the substantia nigra (SN) while Lewy bodies are still present. As a result, both motor-ridity, tremor, and bradykinesia-and non-motor symptoms such as anxiety and depression. Nowadays, it is well known that the cause behind Parkinson's disease is mainly environmental changes, genetic susceptibility, and toxins. Unfortunately, there is no cure for the disease but treatments. The replacement of lost neurons, α-synuclein and apomorphine, is currently being studied for new therapies. This article focuses on history, mechanism, factors causing Parkinson's disease as well as future therapies for the cure of the diseases. METHODOLOGY: Data were collected from medical journals published on PubMed, The Lancet, Cells, and Nature Reviews Neurology databases with a predefined search strategy. All articles considering new therapies for Parkinson's disease were considered.
resultsThe pathophysiology of Parkinson's disease is currently reasonably understood. However, there is no definitive cure so all the treatments focus mainly on reducing or limiting the symptoms. Current treatment studies focus on genetics, replacing lost neurons, α-synuclein and apomorphine.
conclusionParkinson's disease is the most common movement disorder worldwide because of the loss of dopaminergic neurons in the substantia nigra. Its symptoms include motor dysfunctions such as rigidity, tremor, and bradykinesia and non-motor dysfunctions such as anxiety and depression. Through genetics, environmental changes and toxins analysis, it is now known that future new therapies are working on replacing lost neurons, α-synuclein and apomorphine.
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