Evidence map›Paper›PMID 35451212›Full record

ArticleESC heart failure2022

Assessment of cardiac recovery in patients supported with venoarterial extracorporeal membrane oxygenation.

Ravi Vuthoori, Cassandra Heaney, Brian Lima, Alexis Knisel, Ed Miller, Kevin Kennedy, David Majure, Gerin Stevens, Karl Bocchieri, Hugh Cassiere and 2 more

Abstract read
In one paragraph

Article in ESC heart failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ravi VuthooriDonald and Barbara Zucker School of Medicine at Hofstra/Northwell, Uniondale, NY, USA.
Cassandra HeaneyDonald and Barbara Zucker School of Medicine at Hofstra/Northwell, Uniondale, NY, USA.ORCID 0000-0002-8557-1317
Brian LimaDepartment of Cardiovascular and Thoracic Surgery at North Shore University Hospital, Manhasset, NY, USA.
Alexis KniselDonald and Barbara Zucker School of Medicine at Hofstra/Northwell, Uniondale, NY, USA.
Ed MillerRDS2 Solutions Research Division, Stony Brook, NY, USA.
Kevin KennedyStatistical Consultant for Northwell Health, Kansas City, MO, USA.
David MajureDonald and Barbara Zucker School of Medicine at Hofstra/Northwell, Uniondale, NY, USA.
Gerin StevensDonald and Barbara Zucker School of Medicine at Hofstra/Northwell, Uniondale, NY, USA.
Karl BocchieriDepartment of Cardiovascular and Thoracic Surgery at North Shore University Hospital, Manhasset, NY, USA.
Hugh CassiereDonald and Barbara Zucker School of Medicine at Hofstra/Northwell, Uniondale, NY, USA.
Harold FernandezDepartment of Cardiovascular and Thoracic Surgery at North Shore University Hospital, Manhasset, NY, USA.
Simon MaybaumDonald and Barbara Zucker School of Medicine at Hofstra/Northwell, Uniondale, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsVenoarterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly being used to support patients in cardiogenic shock (CS). Early determination of disposition is paramount, as longer durations of support have been associated with worse outcomes. We describe a stepwise, bedside weaning protocol to assess cardiopulmonary recovery during VA-ECMO. METHODS AND

resultsOver 1 year, we considered all patients on VA-ECMO for CS for the Weaning Protocol (WP) at our centre. During the WP, patients had invasive haemodynamic monitoring, echocardiography, and blood gas analysis while flow was reduced in 1 LPM decrements. Ultimately, the circuit was clamped for 30 min, and final measures were taken. Patients were described as having durable recovery (DR) if they were free of pharmacological and mechanical support at 30 days post-decannulation. Over 12 months, 34 patients had VA-ECMO for CS. Fourteen patients were eligible for the WP at 4-12 days. Ten patients tolerated full flow reduction and were successfully decannulated. Twenty-four per cent of the entire cohort demonstrated DR with no adverse events during the WP. Patients with DR had significantly higher ejection fraction, cardiac index, and smaller left ventricular size at lowest flow during the WP.

conclusionsWe describe a safe, stepwise, bedside weaning protocol to assess cardiac recovery during VA-ECMO. Early identification of patients more likely to recover may improve outcomes during ECMO support.

Indexed as

Extracorporeal Membrane OxygenationHeartHumansShock, CardiogenicStroke VolumeVentricular Function, LeftCardiac recoveryCardiogenic shockMechanical circulatory supportVA-ECMO

Identifiers

PMID35451212
PMCPMC9288741

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.