Evidence map›Paper›PMID 35451178›Full record

ArticlePhysiological reports2022

Baroreflex sensitivity in facioscapulohumeral muscular dystrophy.

Miguel Anselmo, Shandon Coffman, Mia Larson, Kathryn Vera, Emma Lee, Mary McConville, Michael Kyba, Manda L Keller-Ross

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Miguel AnselmoDivision of Physical Therapy, Medical School, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0002-8451-234X
Shandon CoffmanSidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Mia LarsonDivision of Physical Therapy, Medical School, University of Minnesota, Minneapolis, Minnesota, USA.
Kathryn VeraDivision of Physical Therapy, Medical School, University of Minnesota, Minneapolis, Minnesota, USA.
Emma LeeDivision of Physical Therapy, Medical School, University of Minnesota, Minneapolis, Minnesota, USA.
Mary McConvilleCollege of Saint Benedict, St. Joseph, Minnesota, USA.
Michael KybaDepartment of Pediatrics and Lillehei Heart Institute, University of Minnesota, Minneapolis, Minnesota, USA.
Manda L Keller-RossDivision of Physical Therapy, Medical School, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0001-9363-5379
Innovative Design Labs (United States) · USCollege of Saint Benedict and Saint John's University · USThomas Jefferson University · USUniversity of Wisconsin–River Falls · US

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR002494 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, WEISDORF, DANIEL J · 2018 to 2022
$34.9M
Probing the Activity of DUX4 in FSHDR01AR055685 · NIAMS · UNIVERSITY OF MINNESOTA · PI Michael Kyba · 2010 to 2026
$7.0M
Training Grant: Functional Proteomics of AgingT32AG029796 · NIA · UNIVERSITY OF MINNESOTA · PI EDGAR A ARRIAGA, Douglas G Mashek · 2008 to 2026
$6.6M
Autonomic regulation of blood pressure in premature and early menopausal womenK01AG064038 · NIA · UNIVERSITY OF MINNESOTA · PI KELLER-ROSS, MANDA LINEA · 2020 to 2024
$647k
NCATS NIH HHS UL1 TR002494NIAMS NIH HHS R01 AR055685NIA NIH HHS K01 AG064038NIA NIH HHS T32 AG029796
6 · The paper itself

Abstract

Facioscapulohumeral muscular dystrophy (FSHD), a common form of muscular dystrophy, is caused by a genetic mutation that alters DUX4 gene expression. This mutation contributes to significant skeletal muscle loss. Although it is suggested that cardiac muscle may be spared, people with FSHD have demonstrated autonomic dysregulation. It is unknown if baroreflex function, an important regulator of blood pressure (BP), is impaired in people with FSHD. We examined if baroreflex sensitivity (BRS) is blunted in patients with FSHD. Thirty minutes of resting BP, heart rate, and cardiovagal BRS were measured in 13 patients with FSHD (age: 50 ± 13 years, avg ± SD) and 17 sex- and age-matched controls (age: 47 ± 14 years, p > 0.05). People with FSHD were less active (Activity Metabolic Index, AMI) (FSHD: 24 ± 30; controls: 222 ± 175 kcal/day; p < 0.001) but had a similar body mass index compared with controls (FSHD: 27 ± 4; controls: 27 ± 4 kg/m

Indexed as

Muscular Dystrophy, FacioscapulohumeralAdultBaroreflexBlood PressureGenes, HomeoboxHomeodomain ProteinsHumansMiddle AgedMuscle, SkeletalHomeodomain Proteinsautonomic functionblood pressureFSHDheart rate variabilitymuscular dystrophy

Identifiers

PMID35451178
PMCPMC9023871
OpenAlexW4225823708

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.