Evidence map›Paper›PMID 35451136›Full record

ArticleContact dermatitis2022

Contact allergy in children with and without atopic dermatitis: An Italian multicentre study.

Domenico Bonamonte, Katharina Hansel, Paolo Romita, Anna Belloni Fortina, Giampiero Girolomoni, Gabriella Fabbrocini, Cataldo Patruno, Maddalena Napolitano, Annalisa Patrizi, Giuseppe Argenziano and 5 more

Open access · hybridAbstract readMulticenter Study
In one paragraph

Article in Contact dermatitis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 4 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 4 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Pooled it
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  5. Article
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  10. Allergens in Atopic Dermatitis.Clinical reviews in allergy & immunology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 11 institutions in 1 country.

Domenico BonamonteSection of Dermatology, Department of Biomedical Science and Human Oncology, University of Bari "Aldo Moro", Bari, Italy.ORCID https://orcid.org/0000-0002-1319-4946
Katharina HanselSection of Dermatology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.ORCID https://orcid.org/0000-0002-6674-4278
Paolo RomitaSection of Dermatology, Department of Biomedical Science and Human Oncology, University of Bari "Aldo Moro", Bari, Italy.
Anna Belloni FortinaUnit of Pediatric Dermatology, Department of Medicine DIMED, University of Padua, Padua, Italy.ORCID https://orcid.org/0000-0001-5791-0775
Giampiero GirolomoniSection of Dermatology, Department of Medicine, University of Verona, Verona, Italy.
Gabriella FabbrociniSection of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Italy.
Cataldo PatrunoDepartment of Health Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy.
Maddalena NapolitanoDepartment of Medicine and Health Sciences Vincenzo Tiberio, University of Molise, Campobasso, Italy.
Annalisa PatriziUnit of Dermatology, IRCCS Azienda Ospedaliero Universitaria, University of Bologna, Bologna, Italy.
Giuseppe ArgenzianoDermatology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, Naples, Italy.
Giuseppe MicaliDermatology Clinic, University of Catania, Catania, Italy.ORCID https://orcid.org/0000-0002-5157-3939
Piergiacomo Calzavara PintonDermatology Department, University of Brescia, Brescia, Italy.
Caterina FotiSection of Dermatology, Department of Biomedical Science and Human Oncology, University of Bari "Aldo Moro", Bari, Italy.ORCID https://orcid.org/0000-0001-6196-9788
Luca StingeniSection of Dermatology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.ORCID https://orcid.org/0000-0001-7919-8141
Italian Society of Dermatology and Venereology, Pediatric Dermatology Group
University of Bari Aldo Moro · ITUniversity of Perugia · ITAzienda USL di Bologna · ITMagna Graecia University · ITUniversity of Brescia · ITUniversity of Campania "Luigi Vanvitelli" · ITUniversity of Catania · ITUniversity of Molise · ITUniversity of Naples Federico II · ITUniversity of Padua · ITUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundContact allergy and atopic dermatitis (AD) are both common inflammatory T cell-mediated diseases and many factors may influence the prevalence of contact allergy in AD patients. In children, their possible correlation was debated with conflicting results.

objectivesThe present study aimed to assess the prevalence of contact sensitivity in children and to investigate the association with AD. MATERIALS AND

methodsA retrospective multicentre study on children aged from 0 to 14 years patch tested between January 2017 and December 2018 was performed. Children were consecutively patch tested with the SIDAPA (Società Italiana Dermatologia Allergologica Professionale Ambientale) baseline series.

resultsAmong the 432 children investigated for contact allergy, 125 (28.9%) showed a positive reaction to at least one of the allergens tested, with a higher prevalence of positive patch test reactions in girls (32.3%) than in boys (25.0%). The most frequent contact allergens were nickel sulphate (10.2%), cobalt chloride (6.7%), methylisothiazolinone (3.7%), fragrance mix-2 (3.2%), potassium dichromate (2.8%), fragrance mix-1 (2.1%) and methylchloroisothiazolinone/methylisothiazolinone (2.1%). One-hundred-three children (23.8%) suffered from AD showing a higher prevalence of positive patch test (36.9%) compared to children without AD (26.4%).

conclusionsDespite the topic being still controversial, the present study suggests a consistent prevalence of contact allergy among children with higher sensitivity rate among children with AD than without AD.

Indexed as

Dermatitis, Allergic ContactDermatitis, AtopicAllergensChildFemaleHumansMalePatch TestsPotassium DichromatePrevalenceRetrospective StudiesAllergensPotassium Dichromateatopic dermatitischildrencontact allergypatch testing

Identifiers

PMID35451136
PMCPMC9541036
OpenAlexW4224231644

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.