ArticleThe journal of nutrition, health & aging2022
Accelerated Epigenetic Aging Mediates the Association between Vitamin D Levels and Knee Pain in Community-Dwelling Individuals.
Article in The journal of nutrition, health & aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The trial behind it
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Borderline acceleration in blood epigenetic age of unclear biological importance in knee osteoarthritis progression: Specimens and data from the Osteoarthritis Initiative and Johnston County Osteoarthritis Project.Osteoarthritis and cartilage · 2026Article
- Pain and Nutrition in Dementia and Alzheimer's Phase 1: a cross-sectional, observational study design.Frontiers in dementia · 2026Article
- Article
- Non-linear association between serum levels of vitamins A and B12 and accelerated epigenetic aging.Frontiers in nutrition · 2025Article
- Socioeconomic Status, Knee Pain, and Epigenetic Aging in Community-Dwelling Middle-to-Older Age Adults.The journal of pain · 2024Article
- Differential DNA methylation profiles of Alzheimer's disease-related genomic pathways in the blood of cognitively-intact individuals with and without high impact chronic pain.Journal of Alzheimer's disease reports · 2024Article
- Epigenetic age acceleration mediates the relationship between neighborhood deprivation and pain severity in adults with or at risk for knee osteoarthritis pain.Social science & medicine (1982) · 2023Article
- Pain interference mediates the association between epigenetic aging and grip strength in middle to older aged males and females with chronic pain.Frontiers in aging neuroscience · 2023Article
- Vitamin D Metabolism Genes Are Differentially Methylated in Individuals with Chronic Knee Pain.Lifestyle genomics · 2023Article
- Clinical vitamin D levels are associated with insular volume and inferior temporal gyrus white matter surface area in community-dwelling individuals with knee pain.Frontiers in neuroscience · 2022Article
- Editorial: Epigenetic Clock: A Novel Tool for Nutrition Studies of Healthy Ageing.The journal of nutrition, health & aging · 2022Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesTo examine the relationship between Vitamin D status and pain intensity and disability in individuals with and without knee pain, and to examine the role of epigenetics in this relationship.
designCross-sectional analysis of data from the UPLOAD-2 study (Understanding Pain and Limitations in OsteoArthritic Disease-2).
participants189 individuals aged 45-65 years and older. MEASUREMENTS: Serum Vitamin D levels, pain related interference and characteristic pain intensity measures, and the epigenetic clock GrimAge derived from blood analyses.
resultsLower Vitamin D was associated with advanced epigenetic aging (AgeAccelGrim), greater pain and disability and that (AgeAccelGrim) mediated the relationship between Vitamin D status and self-reported pain (ab = -0.0799; CI [-0.1492, -0.0237]) and disability (ab = -0.0669; CI [-0.1365, -0.0149]) outcomes.
conclusionThese data support the notion that lifestyle factors such as nutrition status play a key role in aging process, as well as the development and maintenance of age-related diseases such as pain. Modifying nutrition status could help promote healthy aging and reduce pain.
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Registered trials
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