Evidence map›Paper›PMID 35450779›Full record

ReviewTrends in biotechnology2022

Nano toolbox in immune modulation and nanovaccines.

Mohammad Azharuddin, Geyunjian Harry Zhu, Anirban Sengupta, Jorma Hinkula, Nigel K H Slater, Hirak K Patra

Abstract readReview
In one paragraph

Review in Trends in biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. AVaccines · 2026
    Article
  2. Review
  3. Harnessing Nanocarriers to Advance Vaccine Development.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026
    Review
  4. Article
  5. Article
  6. Article
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  8. Review
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  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mohammad AzharuddinDepartment of Biomedical and Clinical Sciences (BKV), Linköping University, Linköping, Sweden.
Geyunjian Harry ZhuDepartment of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK.
Anirban SenguptaDepartment of Biomedical and Clinical Sciences (BKV), Linköping University, Linköping, Sweden.
Jorma HinkulaDepartment of Biomedical and Clinical Sciences (BKV), Linköping University, Linköping, Sweden.
Nigel K H SlaterDepartment of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK.
Hirak K PatraDepartment of Surgical Biotechnology, University College London, London, UK. Electronic address: hirak.patra@ucl.ac.uk.

Funding

Medical Research Council MR/T030968/1
6 · The paper itself

Abstract

Despite the great success of vaccines over two centuries, the conventional strategy is based on attenuated/altered microorganisms. However, this is not effective for all microbes and often fails to elicit a protective immune response, and sometimes poses unexpected safety risks. The expanding nano toolbox may overcome some of the roadblocks in vaccine development given the plethora of unique nanoparticle (NP)-based platforms that can successfully induce specific immune responses leading to exciting and novel solutions. Nanovaccines necessitate a thorough understanding of the immunostimulatory effect of these nanotools. We present a comprehensive description of strategies in which nanotools have been used to elicit an immune response and provide a perspective on how nanotechnology can lead to future personalized nanovaccines.

Indexed as

NanoparticlesVaccinesImmunityNanotechnologyVaccinesimmune modulationimmune responsenano toolboxnanovaccinevaccine

Identifiers

PMID35450779
PMCPMC10439010

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.