Evidence map›Paper›PMID 35450413›Full record

ArticleOxidative medicine and cellular longevity2022

Kindlin-2 Promotes Chondrogenesis and Ameliorates IL-1beta-Induced Inflammation in Chondrocytes Cocultured with BMSCs in the Direct Contact Coculture System.

Zhefeng Chen, Kai Shen, Ziyang Zheng, Jinchun Zhou, Shujie Zhao, Huanghe Song, Jiuxiang Liu, Xuan Zhao, Feng Liu, Qiang Zuo

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Zhefeng ChenDepartment of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Kai ShenDepartment of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.ORCID https://orcid.org/0000-0003-4699-1869
Ziyang ZhengDepartment of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Jinchun ZhouDepartment of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Shujie ZhaoDepartment of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Huanghe SongDepartment of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Jiuxiang LiuDepartment of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Xuan ZhaoDepartment of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Feng LiuDepartment of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.ORCID https://orcid.org/0000-0002-3602-3840
Qiang ZuoDepartment of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.ORCID https://orcid.org/0000-0003-0840-4109
Jiangsu Province Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The osteoarthritis caused by trauma or inflammation is associated with severe patient morbidity and economic burden. Accumulating studies are focusing on the repair of articular cartilage defects by constructing tissue-engineered cartilage. Recent evidence suggests that optimizing the source and quality of seed cells is one of the key points of cartilage tissue engineering. In this study, we demonstrated that Kindlin-2 and its activated PI3K/AKT signaling played an essential role in promoting extracellular matrix (ECM) secretion and ameliorating IL-1beta-induced inflammation in chondrocytes cocultured with bone marrow stem cells (BMSCs).

Indexed as

Cartilage, ArticularMesenchymal Stem CellsCell DifferentiationCells, CulturedChondrocytesChondrogenesisCoculture TechniquesHumansInflammationMembrane ProteinsNeoplasm ProteinsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktFERMT2 protein, humanMembrane ProteinsNeoplasm ProteinsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-akt

Identifiers

PMID35450413
PMCPMC9018182
OpenAlexW4223452541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.