Evidence map›Paper›PMID 35450121›Full record

ArticleFrontiers in public health2022

Large-Scale SARS-CoV-2 Antigen Testing With Real-World Specimens.

Ashish Parikh, Lauren Cooper, Daniel Frogel, Kerry Le Benger, Charles K Cooper, Valentin Parvu

Open access · goldAbstract read
In one paragraph

Article in Frontiers in public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Virus variant-specific clinical performance of a SARS-CoV-2 rapid antigen test with focus on Omicron variants of concern.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2023
    Article
  5. Article
  6. Clinical performance evaluation of BD SARS-CoV-2 reagents for BD MAXDiagnostic microbiology and infectious disease · 2023
    Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Ashish ParikhCityMD/Summit Medical Group, New York, NY, United States.
Lauren CooperBecton, Dickinson and Company, BD Life Sciences-Integrated Diagnostic Solutions, Sparks, MD, United States.
Daniel FrogelCityMD/Summit Medical Group, New York, NY, United States.
Kerry Le BengerCityMD/Summit Medical Group, New York, NY, United States.
Charles K CooperGeorge Mason University, School of Systems Biology, Manassas, VA, United States.
Valentin ParvuBecton, Dickinson and Company, BD Life Sciences-Integrated Diagnostic Solutions, Sparks, MD, United States.
Summit Medical Group (United States) · USBecton Dickinson (United States) · USGeorge Mason University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Real-world data are needed to establish SARS-CoV-2 rapid antigen testing (RAT) as an effective and reliable approach for SARS-CoV-2 screening. This study included 1,952,931 individuals who provided upper respiratory specimens during SARS-CoV-2 screening at CityMD urgent care locations in the New York metropolitan area from October 2020 to March 2021. Positive and negative results, as determined by the BD Veritor™ System for Rapid Detection of SARS-CoV-2 antigen (Veritor), were obtained for all individuals, with reflex reverse transcriptase-polymerase chain reaction (RT-PCR) testing performed on a case-by-case basis, per standard of care. Using verification bias adjustment, two alternative model assumptions were utilized for RAT results with missing reflex RT-PCR results. The worst antigen diagnostic performance estimates asserted that missing RT-PCR results would show a distribution similar to those RT-PCR results actually obtained, based on symptom category. The best antigen diagnostic performance estimates asserted that individuals without RT-PCR results had a clinical presentation consistent with RAT results, and, therefore, missing RT-PCR results would agree with RAT results. For patients with symptoms or high-risk exposure, 25.3% (

Indexed as

COVID-19COVID-19 Serological TestingCOVID-19 Nucleic Acid TestingHumansSARS-CoV-2Sensitivity and SpecificityBD VeritorCOVID-19point-of-carerapid antigen testingreal-world evidence (RWE)RT-PCRSARS-CoV-2

Identifiers

PMID35450121
PMCPMC9016156
OpenAlexW4225701399

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.