Evidence map›Paper›PMID 35450083›Full record

ArticleOpen forum infectious diseases2022

Rates of Severe Influenza-Associated Outcomes Among Older Adults Living With Diabetes-Influenza Hospitalization Surveillance Network (FluSurv-NET), 2012-2017.

Daniel Owusu, Melissa A Rolfes, Carmen S Arriola, Pam Daily Kirley, Nisha B Alden, James Meek, Evan J Anderson, Maya L Monroe, Sue Kim, Ruth Lynfield and 10 more

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
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  14. Influenza vaccination in patients affected by diabetes.European heart journal supplements : journal of the European Society of Cardiology · 2023
    Article
  15. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 13 institutions in 1 country.

Daniel OwusuEpidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0003-0114-5829
Melissa A RolfesInfluenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Carmen S ArriolaInfluenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Pam Daily KirleyCalifornia Emerging Infections Program, Oakland, California, USA.
Nisha B AldenColorado Department of Public Health and Environment, Denver, Colorado, USA.
James MeekConnecticut Emerging Infections Program, Yale School of Public Health, New Haven, Connecticut, USA.
Evan J AndersonDepartment of Medicine and Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0002-1576-4420
Maya L MonroeMaryland Department of Health, Baltimore, Maryland, USA.
Sue KimMichigan Department of Health and Human Services, Lansing, Michigan, USA.
Ruth LynfieldMinnesota Department of Health, St Paul, Minnesota, USA.
Kathy AngelesNew Mexico Department of Health, Santa Fe, New Mexico, USA.
Nancy SpinaNew York State Department of Health, Albany, New York, USA.
Christina B FelsenUniversity of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
Laurie BillingOhio Department of Health, Columbus, Ohio, USA.
Ann ThomasOregon Public Health Authority, Portland, Oregon, USA.
H Keipp TalbotVanderbilt University School of Medicine, Nashville, Tennessee, USA.
William SchaffnerVanderbilt University School of Medicine, Nashville, Tennessee, USA.
Ryan ChatelainSalt Lake County Health Department, Salt Lake City, Utah, USA.
Carrie ReedInfluenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0001-7944-7638
Shikha GargInfluenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Centers for Disease Control and Prevention · USVanderbilt University · USColorado Department of Public Health and Environment · USEmory University · USLake County · USMaryland Department of Health · USMichigan Department of Health and Human Services · USMinnesota Department of Health · USNew Mexico Department of Health · USNew York State Department of Health · USOhio Department of Health · USOregon Health Authority · USUniversity of Rochester · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Diabetes mellitus (DM) is common among older adults hospitalized with influenza, yet data are limited on the impact of DM on risk of severe influenza-associated outcomes. Methods: We included adults aged ≥65 years hospitalized with influenza during 2012-2013 through 2016-2017 from the Influenza Hospitalization Surveillance Network (FluSurv-NET), a population-based surveillance system for laboratory-confirmed influenza-associated hospitalizations conducted in defined counties within 13 states. We calculated population denominators using the Centers for Medicare and Medicaid Services county-specific DM prevalence estimates and National Center for Health Statistics population data. We present pooled rates and rate ratios (RRs) of intensive care unit (ICU) admission, pneumonia diagnosis, mechanical ventilation, and in-hospital death for persons with and without DM. We estimated RRs and 95% confidence intervals (CIs) using meta-analysis with site as a random effect in order to control for site differences in the estimates. Results: Of 31 934 hospitalized adults included in the analysis, 34% had DM. Compared to those without DM, adults with DM had higher rates of influenza-associated hospitalization (RR, 1.57 [95% CI, 1.43-1.72]), ICU admission (RR, 1.84 [95% CI, 1.67-2.04]), pneumonia (RR, 1.57 [95% CI, 1.42-1.73]), mechanical ventilation (RR, 1.95 [95% CI, 1.74-2.20]), and in-hospital death (RR, 1.48 [95% CI, 1.23-1.80]). Conclusions: Older adults with DM have higher rates of severe influenza-associated outcomes compared to those without DM. These findings reinforce the importance of preventing influenza virus infections through annual vaccination, and early treatment of influenza illness with antivirals in older adults with DM.

Indexed as

diabetes mellitusinfluenzainfluenza hospitalizationsevere influenza outcomes

Identifiers

PMID35450083
PMCPMC9017364
OpenAlexW4220711018

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.