ArticleJournal of medicine and life2022
The effect of Crocin on sperm parameters disorders induced by peripheral administration of nitrosamines in male rats.
Article in Journal of medicine and life, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 7 citations in OpenAlex.
- Reproductive and developmental toxicology of nitrosamines.Toxicology research · 2025Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitrosamines are carcinogenic agents which can unfavorably affect some male reproductive parameters. Humans are exposed to nitrosamines through various routes, the most important of which is the diet. Crocin is a carotenoid and is accountable for the red color of saffron. Crocin has numerous pharmacological actions, such as antioxidant roles and radical scavenging. The aim of this study was to evaluate the effects of Crocin against Nitrosamine - induced damage to the reproductive parameter of male rats. In this experimental study, 48 male rats were randomly assigned to 8 groups: control normal and Nitrosamine control groups (40 mg/kg); Crocin (12.5, 25, and 50 mg/kg) and Nitrosamine + Crocin (12.5, 25, and 50 mg/kg). Treatments were administered intraperitoneally and gavaged daily for 28 days. The sperm parameters, total antioxidant capacity, testosterone level, and seminiferous tube diameter were assessed. Nitrosamine significantly decreased sperm parameters (p<0.001). The Crocin and Crocin + Nitrosamine treatments at complete doses significantly improved all parameters (p<0.001). Crocin compensated for the toxic effect of Nitrosamine on reproductive parameters.
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