Evidence map›Paper›PMID 35449999›Full record

SynthesisJournal of medicine and life2022

A systematic review on chlorine dioxide as a disinfectant.

Umi Haida Nadia Mohamed Jefri, Abdullah Khan, Ya Chee Lim, Kah Seng Lee, Kai Bin Liew, Yaman Walid Kassab, Chee-Yan Choo, Yaser Mohammed Al-Worafi, Long Chiau Ming, Anandarajagopal Kalusalingam

Open access · diamondAbstract readSystematic Review
In one paragraph

Synthesis in Journal of medicine and life, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
77.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 396 citations in OpenAlex.

  1. Article
  2. Differential Responses ofMicroorganisms · 2026
    Article
  3. Article
  4. Article
  5. Frontiers in veterinary science · 2026
    Review
  6. Biomaterial investigations in dentistry · 2026
    Article
  7. Article
  8. Article
  9. Granular polymers with immobilizedJournal of water and health · 2025
    Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Airborne transmission of common swine viruses.Porcine health management · 2023
    Review
  18. ClOMolecules (Basel, Switzerland) · 2023
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 4 countries.

Umi Haida Nadia Mohamed JefriPAP Rashidah Sa'adatul Bolkiah Institute of Health Sciences, Universiti Brunei Darussalam, Gadong, Brunei Darussalam.
Abdullah KhanSchool of Pharmacy, KPJ Healthcare University College, Nilai, Malaysia.
Ya Chee LimPAP Rashidah Sa'adatul Bolkiah Institute of Health Sciences, Universiti Brunei Darussalam, Gadong, Brunei Darussalam.
Kah Seng LeeFaculty of Pharmacy, University of Cyberjaya, Cyberjaya, Malaysia.
Kai Bin LiewFaculty of Pharmacy, University of Cyberjaya, Cyberjaya, Malaysia.
Yaman Walid KassabCollege of Pharmacy, National University of Science and Technology, Muscat, Oman.
Chee-Yan ChooFaculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam, Malaysia.
Yaser Mohammed Al-WorafiCollege of Pharmacy, University of Science and Technology of Fujairah, Fujairah, United Arab Emirates.
Long Chiau MingPAP Rashidah Sa'adatul Bolkiah Institute of Health Sciences, Universiti Brunei Darussalam, Gadong, Brunei Darussalam.
Anandarajagopal KalusalingamSchool of Pharmacy, KPJ Healthcare University College, Nilai, Malaysia.
Universiti Brunei Darussalam · BNKPJ Healthcare UniversityUniversity of Cyberjaya · MYMuscat College · OMUniversiti Teknologi MARA · MYUniversity of Science and Technology of Fujairah

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The COVID-19 pandemic has tremendously increased the production and sales of disinfectants. This study aimed to systematically review and analyze the efficacy and safety of chlorine dioxide as a disinfectant. The literature relating to the use of chlorine dioxide as a disinfectant was systematically reviewed in January 2021 using databases such as PubMed, Science Direct, and Google Scholar. Inclusion criteria were studies that investigated the use of chlorine dioxide to assess the efficacy, safety, and impact of chlorine dioxide as a disinfectant. Out of the 33 included studies, 14 studies focused on the disinfectant efficacy of chlorine dioxide, 8 studies expounded on the safety and toxicity in humans and animals, and 15 studies discussed the impact, such as water treatment disinfection using chlorine dioxide. Chlorine dioxide is a safe and effective disinfectant, even at concentrations as low as 20 to 30 mg/L. Moreover, the efficacy of chlorine dioxide is mostly independent of pH. Chlorine dioxide can be effectively used to disinfect drinking water without much alteration of palatability and can also be used to destroy pathogenic microbes, including viruses, bacteria, and fungi from vegetables and fruits. Our review confirms that chlorine dioxide is effective against the resistant

Indexed as

COVID-19DisinfectantsInfluenza A Virus, H1N1 SubtypeAnimalsChlorineChlorine CompoundsHumansOxidesPandemicsChlorineChlorine Compoundschlorine dioxideDisinfectantsOxidesChlorine dioxideCOVID-19disinfectantefficacysafety

Identifiers

PMID35449999
PMCPMC9015185
OpenAlexW4224326480

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.