Evidence map›Paper›PMID 35449948›Full record

ArticleACS omega2022

In Situ Grown Nanohydroxyapatite Hybridized Graphene Oxide: Enhancing the Strength and Bioactivity of Polymer Scaffolds.

Dongying Li, Meigui Chen, Wenmin Guo, Pin Li, Haoyu Wang, Wenhao Ding, Mengqi Li, Yong Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dongying LiKey Laboratory of Hunan Province for Efficient Power System and Intelligent Manufacturing, College of Mechanical and Energy Engineering, Shaoyang University, Shaoyang 422000, China.
Meigui ChenKey Laboratory of Hunan Province for Efficient Power System and Intelligent Manufacturing, College of Mechanical and Energy Engineering, Shaoyang University, Shaoyang 422000, China.
Wenmin GuoKey Laboratory of Hunan Province for Efficient Power System and Intelligent Manufacturing, College of Mechanical and Energy Engineering, Shaoyang University, Shaoyang 422000, China.
Pin LiKey Laboratory of Hunan Province for Efficient Power System and Intelligent Manufacturing, College of Mechanical and Energy Engineering, Shaoyang University, Shaoyang 422000, China.
Haoyu WangKey Laboratory of Hunan Province for Efficient Power System and Intelligent Manufacturing, College of Mechanical and Energy Engineering, Shaoyang University, Shaoyang 422000, China.
Wenhao DingKey Laboratory of Hunan Province for Efficient Power System and Intelligent Manufacturing, College of Mechanical and Energy Engineering, Shaoyang University, Shaoyang 422000, China.
Mengqi LiKey Laboratory of Hunan Province for Efficient Power System and Intelligent Manufacturing, College of Mechanical and Energy Engineering, Shaoyang University, Shaoyang 422000, China.
Yong XuKey Laboratory of Hunan Province for Efficient Power System and Intelligent Manufacturing, College of Mechanical and Energy Engineering, Shaoyang University, Shaoyang 422000, China.ORCID https://orcid.org/0000-0002-2511-638X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Graphene oxide (GO) and nanohydroxyapatite (nHA) are usually used for improving the strength and bioactivity of polymer scaffolds. However, due to the nano-aggregation effect, these applications often face the problems of uneven dispersion and poor interface bonding. In this work, their hybrids (GO@nHA) were constructed by combining chemical modification and in situ growth methods, realizing the perfect combination of nHA and GO. First, the functionalization of GO was realized through oxidative self-polymerization of dopamine (DA), and the product was denoted GO@DA. Furthermore, the in situ growth of nHA on GO@DA was induced by hydrothermal reactions to prepare GO@nHA hybrids. Then, the obtained hybrid was added to the polymer matrix, and a composite scaffold was prepared through a selective laser sintering process. The results demonstrated that with the addition of GO@DA and GO@nHA, the ultimate strength was increased to 16.8 and 18.6 MPa, respectively, which is 66 and 84% higher than the 10.1 MPa of the polylactic acid (PLA) scaffold. In addition, composite scaffolds exhibited good biomineralization ability in vitro and also promoted the adhesion and proliferation of MG63 cells.

Identifiers

PMID35449948
PMCPMC9016834

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.