Evidence map›Paper›PMID 35449921›Full record

ArticleACS omega2022

Serendipitous Discovery of a Highly Active and Selective Resistance-Modifying Agent for Colistin-Resistant Gram-Negative Bacteria.

Yuefeng Gao, Somnath Dutta, Xiang Wang

Abstract read
In one paragraph

Article in ACS omega, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yuefeng GaoDepartment of Chemistry, University of Colorado, Boulder, Colorado 80309, United States.ORCID https://orcid.org/0000-0001-5788-1804
Somnath DuttaDepartment of Chemistry, University of Colorado, Boulder, Colorado 80309, United States.ORCID https://orcid.org/0000-0003-1920-118X
Xiang WangDepartment of Chemistry, University of Colorado, Boulder, Colorado 80309, United States.ORCID https://orcid.org/0000-0003-0396-7404

Funding

Development of Novel Resistance-Modifying Agents for MRSAR33AI121581 · NIAID · UNIVERSITY OF COLORADO · PI WANG, XIANG · 2018 to 2020
$1.4M
NIAID NIH HHS R33 AI121581
6 · The paper itself

Abstract

Antibiotic resistance is a growing global health concern. Colistin is one of the last-resort antibiotics that treats multidrug-resistant (MDR) Gram-negative bacterial infection. However, bacteria resistant to colistin have become increasingly prevalent. Using a bacterial whole-cell screen of a fragment-based library, one compound was discovered to resensitize MDR

Identifiers

PMID35449921
PMCPMC9016814

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.