Evidence map›Paper›PMID 35449901›Full record

ArticleACS omega2022

Metabolic, Pharmacokinetic, and Activity Profile of the Liver Stage Antimalarial (RC-12).

Yuxiang Dong, Yogesh Sonawane, Steven P Maher, Anne-Marie Zeeman, Victor Chaumeau, Amélie Vantaux, Caitlin A Cooper, Francis C K Chiu, Eileen Ryan, Jenna McLaren and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. A Drug Repurposing Approach Reveals Targetable Epigenetic Pathways inbioRxiv : the preprint server for biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 6 countries.

Yuxiang DongCollege of Pharmacy, University of Nebraska Medical Center, 986125 Nebraska Medical Center, Omaha, Nebraska 68198, United States.ORCID https://orcid.org/0000-0003-1412-3178
Yogesh SonawaneCollege of Pharmacy, University of Nebraska Medical Center, 986125 Nebraska Medical Center, Omaha, Nebraska 68198, United States.
Steven P MaherCenter for Tropical and Emerging Global Diseases, University of Georgia, 370 Coverdell Center, 500 D.W. Brooks Drive, Athens, Georgia 30602, United States.ORCID https://orcid.org/0000-0002-9560-5656
Anne-Marie ZeemanDepartment of Parasitology, Biomedical Primate Research Centre, P.O. Box 3306, 2280 GH Rijswijk, The Netherlands.
Victor ChaumeauShoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 68/30 Bantung Road, Mae Sot, Tak 63110, Thailand.ORCID https://orcid.org/0000-0003-0171-2176
Amélie VantauxMalaria Molecular Epidemiology Unit, Institut Pasteur du Cambodge, 5 Boulevard Monivong, P.O. Box 983, Phnom Penh 120 210, Cambodia.
Caitlin A CooperCenter for Tropical and Emerging Global Diseases, University of Georgia, 370 Coverdell Center, 500 D.W. Brooks Drive, Athens, Georgia 30602, United States.
Francis C K ChiuCentre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.
Eileen RyanCentre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.
Jenna McLarenCentre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.
Gong ChenCentre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.
Sergio WittlinDepartment of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Socinstrasse 57, CH-4002 Basel, Switzerland.
Benoît WitkowskiMalaria Molecular Epidemiology Unit, Institut Pasteur du Cambodge, 5 Boulevard Monivong, P.O. Box 983, Phnom Penh 120 210, Cambodia.
François NostenShoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 68/30 Bantung Road, Mae Sot, Tak 63110, Thailand.
Kamaraj SriraghavanCollege of Pharmacy, University of Nebraska Medical Center, 986125 Nebraska Medical Center, Omaha, Nebraska 68198, United States.
Dennis E KyleCenter for Tropical and Emerging Global Diseases, University of Georgia, 370 Coverdell Center, 500 D.W. Brooks Drive, Athens, Georgia 30602, United States.
Clemens H M KockenDepartment of Parasitology, Biomedical Primate Research Centre, P.O. Box 3306, 2280 GH Rijswijk, The Netherlands.
Susan A CharmanCentre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.ORCID https://orcid.org/0000-0003-1753-8213
Jonathan L VennerstromCollege of Pharmacy, University of Nebraska Medical Center, 986125 Nebraska Medical Center, Omaha, Nebraska 68198, United States.ORCID https://orcid.org/0000-0003-0075-2336
Monash University · AUNebraska Medical Center · USUniversity of Georgia · USBiomedical Primate Research Centre · NLInstitut Pasteur du Cambodge · KHMahidol University · THSwiss Tropical and Public Health Institute · CH

Funding

Leveraging RC-12 for Radical Cure of Plasmodium VivaxR21AI103725 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI VENNERSTROM, JONATHAN L · 2013 to 2014
$372k
NIAID NIH HHS R21 AI103725Wellcome Trust 220211
6 · The paper itself

Abstract

The catechol derivative RC-12 (WR 27653) (

Identifiers

PMID35449901
PMCPMC9016807
OpenAlexW4221129566

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.