ArticleCurrent addiction reports2021
SUBSTANCE USE AND ADDICTION AFFECT MORE THAN THE BRAIN: THE PROMISE OF NEUROCARDIAC INTERVENTIONS.
Article in Current addiction reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Heart Rate Variability Biofeedback for Substance Use Disorder: A Randomized Clinical Trial.JAMA psychiatry · 2025Trial
- Development of a Heart Rate Variability Based Ambulatory Stress Detection Model for Clinical Populations.Applied psychophysiology and biofeedback · 2026Article
- Elevated Stress Reactivity: A Barrier to Cannabis Use Change Behavior.Substance use & misuse · 2026Article
- Novel neurotherapeutic targets for substance use disorders: Neuroplasticity, neuroinflammation, gasotransmitters and non-canonical organ systems.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Substance Use is Associated With College Students' Acute Parasympathetic Nervous System Responses to Challenge.Stress and health : journal of the International Society for the Investigation of Stress · 2025Article
- Time Since Last Drink is Positively Associated with Heart Rate Variability in Outpatients with Alcohol Use Disorder: Further Evidence of Psychophysiological Recovery in Early Alcohol Use Disorder Recovery.Applied psychophysiology and biofeedback · 2023Article
- In natura heart rate variability predicts subsequent alcohol use in individuals in early recovery from alcohol use disorder.Addiction biology · 2023Article
- Article
- Severity identification for internet gaming disorder using heart rate variability reactivity for gaming cues: a deep learning approach.Frontiers in psychiatry · 2023Article
- Editorial: Integrated cardiovascular and neural system processes as potential mechanisms of behavior change.Frontiers in psychiatry · 2023Article
- Association between opioid use disorder and blunted heart rate variability among opioid-treated chronic pain patients.Addiction biology · 2022Article
- Heart Rate Variability Biofeedback for Substance Use Disorder: Health Policy Implications.Policy insights from the behavioral and brain sciences · 2022Article
- Aggregating heart rate variability indices across sleep stage epochs ignores significant variance through the night.Sleep medicine · 2022Article
- Use and perceived usefulness of a just-in-time resonance breathing intervention adjunct for substance use disorder: Contextual and physiological predictors.Frontiers in psychiatry · 2022Article
- Mean Versus Variability: Disentangling Stress Effects on Alcohol Lapses Among Individuals in the First Year of Alcohol Use Disorder Recovery.Journal of studies on alcohol and drugs · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Purpose of Review: Addiction and excessive substance use contribute to poor mental and physical health. Much research focuses tightly on neural underpinnings and centrally-acting interventions. To broaden this perspective, this review focuses on bidirectional pathways between the brain and cardiovascular system that are well-documented and provide innovative, malleable targets to bolster recovery and alter substance use behaviors. Recent Findings: Cardiovascular signals are integrated via afferent pathways in networks of distributed brain regions that contribute to cognition, as well as emotion and behavior regulation, and are key antecedents and drivers of substance use behaviors. Heart rate variability (HRV), a biomarker of efficient neurocardiac regulatory control, is diminished by heavy substance use and substance use disorders. Promising evidence-based adjunctive interventions that enhance neurocardiac regulation include HRV biofeedback, resonance paced breathing, and some addiction medications. Summary: Cardiovascular communication with the brain through bidirectional pathways contributes to cognitive and emotional processing but is rarely discussed in addiction treatment. New evidence supports cardiovascular-focused adjunctive interventions for problematic substance use and addiction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.