Evidence map›Paper›PMID 35449872›Full record

ArticleACS food science & technology2021

Detection of Serotonin, Melatonin, and Their Metabolites in Honey.

Tae-Kang Kim, Venkatram R Atigadda, Pawel Brzeminski, Adrian Fabisiak, Edith K Y Tang, Robert C Tuckey, Russel J Reiter, Andrzej T Slominski

Open access · greenAbstract read
In one paragraph

Article in ACS food science & technology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

  1. Melatonergic Regulation of Polyethism and Circadian Foraging inInternational journal of molecular sciences · 2025
    Article
  2. Review
  3. Review
  4. Evolutionary formation of melatonin and vitamin D in early life forms: insects take centre stage.Biological reviews of the Cambridge Philosophical Society · 2024
    Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Nutrients · 2023
    Article
  10. Article
  11. Melatonin: A Neurotrophic Factor?Molecules (Basel, Switzerland) · 2022
    Review
  12. Article
  13. Unravelling Anti-Melanogenic Potency of Edible MushroomsJournal of fungi (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Tae-Kang KimDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama 35294, United States; VA Medical Center, Birmingham, Alabama 35294, United States.
Venkatram R AtigaddaDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama 35294, United States.
Pawel BrzeminskiDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama 35294, United States; Department of Chemistry, University of Warsaw, 02-093 Warsaw, Poland.
Adrian FabisiakDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama 35294, United States; Department of Chemistry, University of Warsaw, 02-093 Warsaw, Poland.
Edith K Y TangSchool of Molecular Sciences, The University of Western Australia, Perth, Western Australia 6009, Australia.
Robert C TuckeySchool of Molecular Sciences, The University of Western Australia, Perth, Western Australia 6009, Australia.
Russel J ReiterDepartment of Cellular and Structural Biology, UT Health Science Center, San Antonio, Texas 77030, United States.
Andrzej T SlominskiDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama 35294, United States; VA Medical Center, Birmingham, Alabama 35294, United States.ORCID 0000-0001-8963-3995
University of Alabama at Birmingham · USThe University of Western Australia · AUThe University of Texas Health Science Center at San Antonio · US

Funding

Mechanism of action and function of novel secosteroid 20(OH)D3 in the skinR01AR073004 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ANDRZEJ T SLOMINSKI · 2018 to 2026
$2.9M
Significance of metabolic activation of lumisterol in the skinR01AR071189 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SLOMINSKI, ANDRZEJ T · 2017 to 2021
$1.6M
Canonical and non-canonical vitamin D activation pathways in systemic lupusR21AI149267 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI RAMAN, CHANDER, SLOMINSKI, ANDRZEJ T · 2020 to 2021
$408k
BLRD VA I01 BX004293NIAID NIH HHS R21 AI149267NIAMS NIH HHS R01 AR071189NIAMS NIH HHS R01 AR073004
6 · The paper itself

Abstract

Melatonin and serotonin, products of tryptophan metabolism, are endogenous neurotransmitters and hormones. We have identified and quantified these metabolites in natural honey from Australia, USA, and Poland using a Xevo G2 XS qTof LC-MS. To help ensure correct product identification, some samples were prepurified by RP-HPLC based on the retention times of standards, prior to LC-MS. The concentrations of the metabolites of interest depended on the source of the honey. For Australian honey, levels for melatonin and 2-hydroxymelatonin were 0.91 and 0.68 ng/g, respectively. Melatonin was detected in one brand of US commercial honey at 0.48 ng/g, while a second brand contained serotonin at 88.2 ng/g. In Polish natural honey, 20.6 ng/g of serotonin and 40.8 ng/g of

Indexed as

2-hydroxymelatoninbeeshoneymelatoninN-acetylserotoninserotonin

Identifiers

PMID35449872
PMCPMC9017714
OpenAlexW3186324599

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.