Evidence map›Paper›PMID 35449607›Full record

ArticleCardiology research and practice2022

Impact of MMP-9 Genetic Polymorphism and Concentration on the Development of Coronary Artery Disease in Ukrainian Population.

Oksana S Pogorielova, Viktoriia V Korniienko, Yaroslav D Chumachenko, Olha A Obukhova, Igor Martsovenko, Viktoriia Yu Harbuzova

Open access · goldAbstract read
In one paragraph

Article in Cardiology research and practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Oksana S PogorielovaDepartment of Internal Medicine with Center of Respiratory Medicine, Sumy State University, Sumy 40007, Ukraine.ORCID https://orcid.org/0000-0003-4077-8637
Viktoriia V KorniienkoBiomedical Research Center, Sumy State University, Sumy 40018, Ukraine.ORCID https://orcid.org/0000-0002-5144-2138
Yaroslav D ChumachenkoScientific Laboratory of Molecular Genetic Studies, Sumy State University, Sumy 40007, Ukraine.ORCID https://orcid.org/0000-0002-4803-5435
Olha A ObukhovaDepartment of Physiology and Pathophysiology with Medical Biology Course, Sumy State University, Sumy 40018, Ukraine.ORCID https://orcid.org/0000-0002-2104-8412
Igor MartsovenkoMunicipal Non-Profit Enterprise of Sumy Regional Council "Sumy Regional Cardiological Clinic", Sumy 40030, Ukraine.
Viktoriia Yu HarbuzovaScientific Laboratory of Molecular Genetic Studies, Sumy State University, Sumy 40007, Ukraine.ORCID https://orcid.org/0000-0001-7183-6997
Sumy State University · UA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronary artery disease (CAD) is one of the leading causes of death in Europe. It is known that atherosclerosis is the primary risk factor of CAD development. MMP-9 is involved in all stages of atherosclerosis and thus may contribute to CAD emergence. To investigate the influence of MMP-9 on the (CAD) development 25 patients with intact coronary arteries (CA), 40 patients with acute coronary syndrome (ACS), and 63 patients with chronic coronary syndrome (CCS) were enrolled in the study. Real-time PCR was carried out for genotyping on the rs17567-polymorphic locus, and ELISA study was performed to measure the MMP-9 plasma concentration. It was found the lower risk of MI occurrence for AG-carriers (

Identifiers

PMID35449607
PMCPMC9017573
OpenAlexW4223494395

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.