Evidence map›Paper›PMID 35449594›Full record

ArticleFrontiers in bioengineering and biotechnology2022

Reduced Genotoxicity of Gold Nanoparticles With Protein Corona in

Sagar S Arya, James E Rookes, David M Cahill, Sangram K Lenka

Open access · goldAbstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Sagar S AryaThe Energy and Resources Institute, TERI-Deakin Nanobiotechnology Centre, Gurugram, India.
James E RookesSchool of Life and Environmental Sciences, Deakin University, Waurn Ponds Campus, Geelong, VIC, Australia.
David M CahillSchool of Life and Environmental Sciences, Deakin University, Waurn Ponds Campus, Geelong, VIC, Australia.
Sangram K LenkaThe Energy and Resources Institute, TERI-Deakin Nanobiotechnology Centre, Gurugram, India.
Deakin University · AUEnergy and Resources Institute · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increased usage of gold nanoparticles (AuNPs) in biomedicine, biosensing, diagnostics and cosmetics has undoubtedly facilitated accidental and unintentional release of AuNPs into specific microenvironments. This is raising serious questions concerning adverse effects of AuNPs on off-target cells, tissues and/or organisms. Applications utilizing AuNPs will typically expose the nanoparticles to biological fluids such as cell serum and/or culture media, resulting in the formation of protein corona (PC) on the AuNPs. Evidence for PC altering the toxicological signatures of AuNPs is well studied in animal systems. In this report, we observed significant genotoxicity in

Indexed as

chromosomal aberrationsgenotoxicityplantprotein coronavanillin capped gold nanoparticles

Identifiers

PMID35449594
PMCPMC9016219
OpenAlexW4226138527

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.