ArticlePlant foods for human nutrition (Dordrecht, Netherlands)2022
In Vitro Anti-Inflammatory Activity of Three Peptides Derived from the Byproduct of Rice Processing.
Article in Plant foods for human nutrition (Dordrecht, Netherlands), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Rice-Derived Peptides Exhibit Wound Healing Properties in Human Keratinocytes: Screening, Identification, and Mechanism Revelation.Plant foods for human nutrition (Dordrecht, Netherlands) · 2026Article
- Novel Peptides LFLLP and DFFL from Jack Bean Protein Hydrolysates Suppress the Inflammatory Response in Lipopolysaccharide-Stimulated RAW 264.7 Cells.Foods (Basel, Switzerland) · 2024Article
- Food-derived bioactive peptides potentiating therapeutic intervention in rheumatoid arthritis.Heliyon · 2024Review
- Insights into characteristic metabolites and potential bioactive peptides profiles of fresh cheese fermented with three novel probiotics based metabolomics and peptidomics.Food chemistry: X · 2024Article
- Study on the structure-activity relationship of rice immunopeptides based on molecular docking.Food chemistry: X · 2024Article
- Plant-Derived Proteins and Peptides as Potential Immunomodulators.Molecules (Basel, Switzerland) · 2023Article
- Generation of Bioactive Peptides fromMarine drugs · 2023Article
- Transcriptome Analysis Reveals the Immunoregulatory Activity of Rice Seed-Derived Peptide PEP1 on Dendritic Cells.Molecules (Basel, Switzerland) · 2023Article
- Alanine Substitution to Determine the Effect of LR5 and YR6 Rice Peptide Structure on Antioxidant and Anti-Inflammatory Activity.Nutrients · 2023Article
- Anti-Inflammatory Function of Plant-Derived Bioactive Peptides: A Review.Foods (Basel, Switzerland) · 2022Review
- Identification and virtual screening of novel anti-inflammatory peptides from broccoli fermented byFrontiers in nutrition · 2022Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflammation is a contributing factor to the initiation and progression of many diseases, and some food-derived biofunctional peptides show high anti-inflammatory activity. In our previous study, we demonstrated that peptides derived from trypsin hydrolysis of rice protein show good immunological activity. In the present study, proteins of broken rice were extracted and identified by macroporous resin fractionation and liquid chromatography/tandem mass spectrometry (LC-MS/MS). Subsequently, a bioinformatics prediction and in silico simulation approach was used to screen for peptides showing anti-inflammatory activity, including inhibition of the production of nitric oxide and proinflammatory cytokines (interleukin-1β, interleukin-6, and tumor necrosis factor-α) by lipopolysaccharide-stimulated RAW264.7 mice macrophages. Three peptides (DNIQGITKPAIR, IAFKTNPNSMVSHIAGK, and IGVAMDYSASSKR) that demonstrated the highest binding affinity were synthesized, and their in vitro anti-inflammatory activity was investigated. This is the first study that integrates LC-MS/MS identification and bioinformatics prediction for reporting the anti-inflammatory activity of anti-inflammatory peptides derived from broken rice protein. The study findings revealed that the peptides derived from the byproduct of rice milling could be potentially used as natural anti-inflammatory alternativities.
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