Evidence map›Paper›PMID 35449244›Full record

ReviewAngiogenesis2022

Trafficking in blood vessel development.

Caitlin R Francis, Erich J Kushner

Abstract readReview
In one paragraph

Review in Angiogenesis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Intracellular Membrane Transport in Vascular Endothelial Cells.International journal of molecular sciences · 2023
    Review
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Caitlin R FrancisDepartment of Biological Sciences, University of Denver, Denver, CO, 80210, USA.
Erich J KushnerDepartment of Biological Sciences, University of Denver, Denver, CO, 80210, USA. Erich.Kushner@du.edu.

Funding

Polarized Protein Trafficking and AngiogenesisR01HL155921 · NHLBI · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI Erich J Kushner · 2022 to 2026
$1.8M
Mechanisms of Delta-like 4 Endocytosis and Notch Activation During Blood Vessel DevelopmentR15HL156106 · NHLBI · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI KUSHNER, ERICH J · 2021 to 2021
$439k
NHLBI NIH HHS R01 HL155921NHLBI NIH HHS R15 HL156106
6 · The paper itself

Abstract

Blood vessels demonstrate a multitude of complex signaling programs that work in concert to produce functional vasculature networks during development. A known, but less widely studied, area of endothelial cell regulation is vesicular trafficking, also termed sorting. After moving through the Golgi apparatus, proteins are shuttled to organelles, plugged into membranes, recycled, or degraded depending on the internal and extrinsic cues. A snapshot of these protein-sorting systems can be viewed as a trafficking signature that is not only unique to endothelial tissue, but critically important for blood vessel form and function. In this review, we will cover how vesicular trafficking impacts various aspects of angiogenesis, such as sprouting, lumen formation, vessel stabilization, and secretion, emphasizing the role of Rab GTPase family members and their various effectors.

Indexed as

Endothelial Cellsrab GTP-Binding ProteinsEndotheliumProtein TransportSignal Transductionrab GTP-Binding ProteinsAngiogenesisBlood vesselDevelopmentEndocytosisEndothelialEndotheliumExocytosisJunctionsLumen formationRecyclingSproutingTraffickingVascular

Identifiers

PMID35449244
PMCPMC9249721

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.