Evidence map›Paper›PMID 35449172›Full record

ArticleNature communications2022

App-based COVID-19 syndromic surveillance and prediction of hospital admissions in COVID Symptom Study Sweden.

Beatrice Kennedy, Hugo Fitipaldi, Ulf Hammar, Marlena Maziarz, Neli Tsereteli, Nikolay Oskolkov, Georgios Varotsis, Camilla A Franks, Diem Nguyen, Lampros Spiliopoulos and 26 more

Abstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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  13. Detecting early signals of COVID-19 outbreaks in 2020 in small areas by monitoring healthcare utilisation databases: first lessons learned from the Italian Alert_CoV project.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors.

Beatrice KennedyDepartment of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Hugo FitipaldiGenetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Lund, Sweden.ORCID 0000-0001-5352-2134
Ulf HammarDepartment of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Marlena MaziarzDiabetic Complications Unit, Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund, Sweden.ORCID 0000-0003-1417-6050
Neli TsereteliGenetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Lund, Sweden.
Nikolay OskolkovDepartment of Biology, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Lund University, Lund, Sweden.
Georgios VarotsisDepartment of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Camilla A FranksDiabetic Complications Unit, Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund, Sweden.
Diem NguyenDepartment of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.ORCID 0000-0002-9680-5772
Lampros SpiliopoulosDiabetic Complications Unit, Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund, Sweden.
Hans-Olov AdamiClinical Effectiveness Group, Institute of Health and Society, University of Oslo, Oslo, Norway.ORCID 0000-0001-9592-5791
Jonas BjörkDivision of Occupational and Environmental Medicine, Lund University, Lund, Sweden.ORCID 0000-0003-1883-2000
Stefan EngblomDivision of Scientific Computing, Department of Information Technology, Uppsala University, Uppsala, Sweden.ORCID 0000-0002-3614-1732
Katja FallClinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden.
Anna Grimby-EkmanBiostatistics, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Jan-Eric LittonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Mats MartinellDepartment of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.
Anna OudinDivision of Occupational and Environmental Medicine, Lund University, Lund, Sweden.
Torbjörn SjöströmNovus Group International AB, Stockholm, Sweden.
Toomas TimpkaDepartment of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.ORCID 0000-0001-6049-5402
Carole H SudreMRC Unit for Lifelong Health and Ageing at UCL, University College London, London, UK.
Mark S GrahamSchool of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
Julien Lavigne du CadetZOE Limited, 164 Westminster Bridge Road, London, SE1 7RW, UK.
Andrew T ChanClinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Richard DaviesZOE Limited, 164 Westminster Bridge Road, London, SE1 7RW, UK.ORCID 0000-0003-2050-3994
Sajaysurya GaneshZOE Limited, 164 Westminster Bridge Road, London, SE1 7RW, UK.
Anna MayZOE Limited, 164 Westminster Bridge Road, London, SE1 7RW, UK.
Sébastien OurselinSchool of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
Joan Capdevila PujolZOE Limited, 164 Westminster Bridge Road, London, SE1 7RW, UK.
Somesh SelvachandranZOE Limited, 164 Westminster Bridge Road, London, SE1 7RW, UK.
Jonathan WolfZOE Limited, 164 Westminster Bridge Road, London, SE1 7RW, UK.ORCID 0000-0002-0530-2257
Tim D SpectorDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.ORCID 0000-0002-9795-0365
Claire J StevesDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.ORCID 0000-0002-4910-0489
Maria F GomezDiabetic Complications Unit, Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund, Sweden.ORCID 0000-0001-6210-3142
Paul W FranksGenetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Lund, Sweden.ORCID 0000-0002-0520-7604
Tove FallDepartment of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden. tove.fall@medsci.uu.se.ORCID 0000-0003-2071-5866

Funding

British Heart FoundationDepartment of HealthMedical Research CouncilWellcome Trust
6 · The paper itself

Abstract

The app-based COVID Symptom Study was launched in Sweden in April 2020 to contribute to real-time COVID-19 surveillance. We enrolled 143,531 study participants (≥18 years) who contributed 10.6 million daily symptom reports between April 29, 2020 and February 10, 2021. Here, we include data from 19,161 self-reported PCR tests to create a symptom-based model to estimate the individual probability of symptomatic COVID-19, with an AUC of 0.78 (95% CI 0.74-0.83) in an external dataset. These individual probabilities are employed to estimate daily regional COVID-19 prevalence, which are in turn used together with current hospital data to predict next week COVID-19 hospital admissions. We show that this hospital prediction model demonstrates a lower median absolute percentage error (MdAPE: 25.9%) across the five most populated regions in Sweden during the first pandemic wave than a model based on case notifications (MdAPE: 30.3%). During the second wave, the error rates are similar. When we apply the same model to an English dataset, not including local COVID-19 test data, we observe MdAPEs of 22.3% and 19.0% during the first and second pandemic waves, respectively, highlighting the transferability of the prediction model.

Indexed as

COVID-19Mobile ApplicationsHospitalsHumansSentinel SurveillanceSweden

Identifiers

PMID35449172
PMCPMC9023535

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.