Evidence map›Paper›PMID 35449104›Full record

ArticleJournal of translational medicine2022

The "Great Debate" at Immunotherapy Bridge 2021, December 1st-2nd, 2021.

Paolo A Ascierto, Lisa H Butterfield, Olivera J Finn, Andrew Futreal, Omid Hamid, Theresa LaVallee, Michael A Postow, Igor Puzanov, Jeffrey Sosman, Bernard A Fox and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 11 institutions in 2 countries.

Paolo A AsciertoDepartment of Melanoma, Cancer Immunotherapy and Innovative Therapy, Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", Naples, Italy. paolo.ascierto@gmail.com.ORCID 0000-0002-8322-475X
Lisa H ButterfieldMicrobiology and Immunology, Parker Institute for Cancer Immunotherapy, University of California, San Francisco, CA, USA.
Olivera J FinnDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Andrew FutrealDivision of Cancer Medicine, Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Omid HamidMedical Oncology, The Angeles Clinic and Research Institute, A Cedar-Sinai Affiliate, Los Angeles, CA, USA.
Theresa LaValleeParker Institute for Cancer Immunotherapy, San Francisco, CA, USA.
Michael A PostowMemorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY, USA.
Igor PuzanovDepartment of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Jeffrey SosmanDivision of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Bernard A FoxEarle A. Chiles Research Institute, Robert W. Franz Cancer Research Center, Providence Cancer Institute, Portland, OR, USA.
Patrick HwuMoffitt Cancer Center, Tampa, FL, USA.
Angeles Clinic and Research Institute · USIstituto Nazionale Tumori IRCCS "Fondazione G. Pascale" · ITMemorial Sloan Kettering Cancer Center · USMoffitt Cancer Center · USNorthwestern University · USParker Institute for Cancer Immunotherapy · USProvidence Portland Medical Center · USRoswell Park Comprehensive Cancer Center · USThe University of Texas MD Anderson Cancer Center · USUniversity of California, San Francisco · USUniversity of Pittsburgh · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Immunoprevention and immunosurveillance of human non-viral cancersR35CA210039 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FINN, OLIVERA J · 2016 to 2022
$6.0M
NCI NIH HHS P30 CA008748NCI NIH HHS R35 CA210039
6 · The paper itself

Abstract

As part of the 2021 Immunotherapy Bridge virtual congress (December 1-2, Naples, Italy), the Great Debate sessions featured experts who were assigned counter opposing views on four important questions in immunotherapy today. The first topic was whether oncolytic viruses or other specific immunomodulators were the more promising approach for intralesional therapy. The second was whether early surrogate endpoints, such as response rate or progression-free survival, correlate with long-term overall survival was considered. Thirdly, whether vaccines can transform cold into hot tumors was discussed and, finally, broad versus deep analytic profiling approaches to gain insights into immune-oncology development were compared. As with previous Bridge congresses, presenters were invited by the meeting Chairs and positions taken during the debates may not have reflected their respective personal view. In addition, the views summarised in this article are based on available evidence but may reflect personal interpretation of these data, clinical experience and subjective opinion of the speaker.

Indexed as

MelanomaHumansImmunologic FactorsImmunotherapyMedical OncologyProgression-Free SurvivalImmunologic FactorsCancer vaccineCheckpoint inhibitorsClinical trialsImmunotherapyNivolumabOverall survivalPembrolizumabProgression-free survival

Identifiers

PMID35449104
PMCPMC9022317
OpenAlexW4224246779

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.