Evidence map›Paper›PMID 35448942›Full record

Trial reportBMC anesthesiology2022

Hemodynamic and antiemetic effects of prophylactic hyoscine butyl-bromide during cesarean section under spinal anesthesia: a randomized controlled trial.

Mostafa Samy Abbas, Shimaa Abbas Hassan, Ahmed Mohamed Abbas, Amr Mohamed Thabet, Ahmed Mostafa Thabet, Magdy Mohammed Mahdy

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04069078 (Prophylactic Use of Iv Hyoscine Butylbromide for Prevention of Bradycardia During Cesarean Section Under Spinal Anaesthesia. a Randomized Controlled Trial), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04069078 phase4completednot on this map

Prophylactic Use of Iv Hyoscine Butylbromide for Prevention of Bradycardia During Cesarean Section Under Spinal Anaesthesia. a Randomized Controlled Trial

TypeinterventionalSponsorAssiut UniversityRan2019 to 2020Enrolled173ConditionsBradycardia, Spinal Anesthetics Causing Adverse Effects in Therapeutic Use, Cesarean Section ComplicationsArmsHyoscine Butylbromide 20 Mg/mL Solution for Injection Ampoule, Normal saline
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Mostafa Samy AbbasAnesthesia and Intensive Care department, Faculty of Medicine, Assiut University, Assiut, Egypt. mostafasamy@aun.edu.eg.
Shimaa Abbas HassanAnesthesia and Intensive Care department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Ahmed Mohamed AbbasObstetrics and Gynaecology department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Amr Mohamed ThabetAnesthesia and Intensive Care department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Ahmed Mostafa ThabetAnesthesia and Intensive Care department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Magdy Mohammed MahdyAnesthesia and Intensive Care department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Assiut University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAbrupt bradycardia and hemodynamic instability during spinal anesthesia for cesarean section are not uncommon and are considered as one of the primary causes of intraoperative nausea and vomiting (IONV). We hypothesized that prophylactic use of hyoscine butyl-bromide (HBB) could improve hemodynamics and reduce IONV in parturients undergoing cesarean section.

methodsA randomized, double-blind placebo-controlled trial was carried out in a tertiary university hospital, patients scheduled for elective cesarean section were equally randomized to receive either IV HBB 20 mg in 1 ml (Hyoscine group) or the same volume of 0.9% saline (Control group), one minute after spinal anesthesia. The primary endpoint was the incidence of intraoperative bradycardia (HR < 50 beats min

resultsOf the 160 subjects randomized, 80 received HBB and 80 received placebo. There was a significant reduction in the incidence of the primary endpoint of intraoperative bradycardia (HR < 50 beats min

conclusionsIn parturients undergoing cesarean section under spinal anesthesia, pretreatment with intravenous HBB was a safe measure for both the mother and the baby to reduce the risk of severe intraoperative bradycardia, but not hypotension. Furthermore, it was associated with less incidence of both IONV and PONV.

trial registrationhttps://clinicaltrials.gov/ct2/show/NCT04069078.

Indexed as

Anesthesia, ObstetricalAnesthesia, SpinalAntiemeticsHypotensionBradycardiaBromidesCesarean SectionDouble-Blind MethodFemaleHemodynamicsHumansPostoperative Nausea and VomitingPregnancyScopolamineAntiemeticsBromidesScopolamineBradycardiaCesarean sectionHyoscine N-ButylbromideSpinal anesthesiaVomiting

Identifiers

PMID35448942
PMCPMC9027476
OpenAlexW4224250332

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.