Evidence map›Paper›PMID 35448715›Full record

ArticleTomography (Ann Arbor, Mich.)2022

An Anthropomorphic Digital Reference Object (DRO) for Simulation and Analysis of Breast DCE MRI Techniques.

Leah Henze Bancroft, James Holmes, Ryan Bosca-Harasim, Jacob Johnson, Pingni Wang, Frank Korosec, Walter Block, Roberta Strigel

Abstract read
In one paragraph

Article in Tomography (Ann Arbor, Mich.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Leah Henze BancroftDepartment of Radiology, University of Wisconsin-Madison, 600 Highland Ave, Madison, WI 53792, USA.ORCID 0000-0002-8455-6270
James HolmesDepartment of Radiology, University of Wisconsin-Madison, 600 Highland Ave, Madison, WI 53792, USA.ORCID 0000-0002-0936-3700
Ryan Bosca-HarasimDepartment of Imaging Physics, Sanford Health, 801 Broadway North, Fargo, ND 58102, USA.
Jacob JohnsonDepartment of Radiology, University of Wisconsin-Madison, 600 Highland Ave, Madison, WI 53792, USA.
Pingni WangDepartment of Medical Physics, University of Wisconsin-Madison, 1111 Highland Avenue, Madison, WI 53705, USA.
Frank KorosecDepartment of Radiology, University of Wisconsin-Madison, 600 Highland Ave, Madison, WI 53792, USA.
Walter BlockDepartment of Radiology, University of Wisconsin-Madison, 600 Highland Ave, Madison, WI 53792, USA.
Roberta StrigelDepartment of Radiology, University of Wisconsin-Madison, 600 Highland Ave, Madison, WI 53792, USA.

Funding

BIOTECHNOLOGY TRAINING PROGRAMT32GM008349 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI FOX, BRIAN G · 1989 to 2019
$22.5M
U.W. RADIOLOGICAL SCIENCES TRAINING PROGRAMT32CA009206 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Bryan Patrick Bednarz · 1985 to 2026
$12.1M
Multicenter Quantitative MRI Assessment of Breast Cancer Therapy ResponseR01CA248192 · NCI · WILLIAM BEAUMONT HOSPITAL RESEARCH INST · PI WEI HUANG, James H Holmes · 2021 to 2026
$2.8M
NCI NIH HHS R01 CA248192NCI NIH HHS T32 CA009206NIGMS NIH HHS T32 GM008349
6 · The paper itself

Abstract

Advances in accelerated magnetic resonance imaging (MRI) continue to push the bounds on achievable spatial and temporal resolution while maintaining a clinically acceptable image quality. Validation tools, including numerical simulations, are needed to characterize the repeatability and reproducibility of such methods for use in quantitative imaging applications. We describe the development of a simulation framework for analyzing and optimizing accelerated MRI acquisition and reconstruction techniques used in dynamic contrast enhanced (DCE) breast imaging. The simulation framework, in the form of a digital reference object (DRO), consists of four modules that control different aspects of the simulation, including the appearance and physiological behavior of the breast tissue as well as the MRI acquisition settings, to produce simulated k-space data for a DCE breast exam. The DRO design and functionality are described along with simulation examples provided to show potential applications of the DRO. The included simulation results demonstrate the ability of the DRO to simulate a variety of effects including the creation of simulated lesions, tissue enhancement modeled by the generalized kinetic model, T1-relaxation, fat signal precession and saturation, acquisition SNR, and changes in temporal resolution.

Indexed as

Contrast MediaMagnetic Resonance ImagingBreastComputer SimulationReproducibility of ResultsContrast Mediabreast MRIDCE MRIdigital reference objectnumerical simulationquantitative imaging biomarker

Identifiers

PMID35448715
PMCPMC9031444

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.