Evidence map›Paper›PMID 35448474›Full record

ArticleMetabolites2022

Characterization of Constituents with Potential Anti-Inflammatory Activity in Chinese Lonicera Species by UHPLC-HRMS Based Metabolite Profiling.

Eva-Maria Pferschy-Wenzig, Sabine Ortmann, Atanas G Atanasov, Klara Hellauer, Jürgen Hartler, Olaf Kunert, Markus Gold-Binder, Angela Ladurner, Elke H Heiß, Simone Latkolik and 11 more

Abstract read
In one paragraph

Article in Metabolites, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Lipid and Metabolite Annotation Using Lipid Data Analyzer.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  2. Identification of the Hypoglycemic Active Components ofMolecules (Basel, Switzerland) · 2024
    Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Eva-Maria Pferschy-WenzigInstitute of Pharmaceutical Sciences, University of Graz, 8010 Graz, Austria.ORCID 0000-0001-8327-0732
Sabine OrtmannInstitute of Pharmaceutical Sciences, University of Graz, 8010 Graz, Austria.
Atanas G AtanasovDepartment of Pharmaceutical Sciences, University of Vienna, 1090 Vienna, Austria.
Klara HellauerInstitute of Pharmaceutical Sciences, University of Graz, 8010 Graz, Austria.
Jürgen HartlerInstitute of Pharmaceutical Sciences, University of Graz, 8010 Graz, Austria.ORCID 0000-0002-1095-6458
Olaf KunertInstitute of Pharmaceutical Sciences, University of Graz, 8010 Graz, Austria.ORCID 0000-0002-7091-5973
Markus Gold-BinderCenter for Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria.
Angela LadurnerDepartment of Pharmaceutical Sciences, University of Vienna, 1090 Vienna, Austria.
Elke H HeißDepartment of Pharmaceutical Sciences, University of Vienna, 1090 Vienna, Austria.
Simone LatkolikDepartment of Pharmaceutical Sciences, University of Vienna, 1090 Vienna, Austria.
Yi-Min ZhaoGuangxi Botanical Garden of Medicinal Plants, Nanning 530023, China.
Pia RaabInstitute of Pharmaceutical Sciences, University of Graz, 8010 Graz, Austria.ORCID 0000-0001-6353-8973
Marlene MonscheinInstitute of Pharmaceutical Sciences, University of Graz, 8010 Graz, Austria.
Nina TrummerInstitute of Pharmaceutical Sciences, University of Graz, 8010 Graz, Austria.
Bola SamuelInstitute of Pharmaceutical Sciences, University of Graz, 8010 Graz, Austria.
Sara CrockettInstitute of Pharmaceutical Sciences, University of Graz, 8010 Graz, Austria.
Jian-Hua MiaoGuangxi Botanical Garden of Medicinal Plants, Nanning 530023, China.
Gerhard G ThallingerInstitute of Biomedical Informatics, Graz University of Technology, 8010 Graz, Austria.
Valery BochkovInstitute of Pharmaceutical Sciences, University of Graz, 8010 Graz, Austria.ORCID 0000-0003-3043-1736
Verena M DirschDepartment of Pharmaceutical Sciences, University of Vienna, 1090 Vienna, Austria.ORCID 0000-0002-9261-5293
Rudolf BauerInstitute of Pharmaceutical Sciences, University of Graz, 8010 Graz, Austria.ORCID 0000-0002-0057-5547

Funding

FWF Austrian Science Fund S10704, S10705, and S10711
6 · The paper itself

Abstract

This study centered on detecting potentially anti-inflammatory active constituents in ethanolic extracts of Chinese Lonicera species by taking an UHPLC-HRMS-based metabolite profiling approach. Extracts from eight different Lonicera species were subjected to both UHPLC-HRMS analysis and to pharmacological testing in three different cellular inflammation-related assays. Compounds exhibiting high correlations in orthogonal projections to latent structures discriminant analysis (OPLS-DA) of pharmacological and MS data served as potentially activity-related candidates. Of these candidates, 65 were tentatively or unambiguously annotated. 7-Hydroxy-5,3',4',5'-tetramethoxyflavone and three bioflavonoids, as well as three C

Indexed as

anti-inflammatoryhoneysuckleLonicerametabolite profilingmultivariate data analysisOPLS-DAtraditional Chinese medicineUHPLC-HRMS

Identifiers

PMID35448474
PMCPMC9027581

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.