Evidence map›Paper›PMID 35448465›Full record

ArticleMetabolites2022

Liver and White/Brown Fat Dystrophy Associates with Gut Microbiota and Metabolomic Alterations in 3xTg Alzheimer's Disease Mouse Model.

Maria Angela Guzzardi, Federica La Rosa, Daniela Campani, Maria Carmen Collado, Daniel Monleon, Andrea Cacciato Insilla, Maria Tripodi, Alessandro Zega, Alessia Dattilo, Maurizia Rossana Brunetto and 3 more

Open access · goldAbstract read
In one paragraph

Article in Metabolites, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 2 countries.

Maria Angela GuzzardiInstitute of Clinical Physiology, National Research Council (CNR), 56124 Pisa, Italy.ORCID 0000-0001-9574-5088
Federica La RosaInstitute of Clinical Physiology, National Research Council (CNR), 56124 Pisa, Italy.
Daniela CampaniDepartment of Surgical, Medical, Molecular Pathology and Critical Care Medicine, Division of Pathology, Pisa University Hospital, 56124 Pisa, Italy.ORCID 0000-0001-5987-734X
Maria Carmen ColladoInstitute of Agrochemistry and Food Technology-National Research Council (IATA-CSIC), 46980 Valencia, Spain.ORCID 0000-0002-6204-4864
Daniel MonleonFaculty of Medicine, Health Research Institute INCLIVA/CIBERFES for Frailty and Healthy Aging, University of Valencia, 46003 Valencia, Spain.ORCID 0000-0002-4803-1573
Andrea Cacciato InsillaDepartment of Surgical, Medical, Molecular Pathology and Critical Care Medicine, Division of Pathology, Pisa University Hospital, 56124 Pisa, Italy.
Maria TripodiInstitute of Clinical Physiology, National Research Council (CNR), 56124 Pisa, Italy.
Alessandro ZegaInstitute of Clinical Physiology, National Research Council (CNR), 56124 Pisa, Italy.
Alessia DattiloScuola Superiore Sant'Anna, 56127 Pisa, Italy.
Maurizia Rossana BrunettoDepartment of Clinical and Experimental Medicine, University of Pisa, 56124 Pisa, Italy.ORCID 0000-0001-8364-9152
Margherita MaffeiInstitute of Clinical Physiology, National Research Council (CNR), 56124 Pisa, Italy.
Ferruccio BoninoInstitute of Biostructure and Bioimaging (IBB), National Research Council (CNR), 80145 Napoli, Italy.ORCID 0000-0001-9942-0328
Patricia IozzoInstitute of Clinical Physiology, National Research Council (CNR), 56124 Pisa, Italy.
Istituto di Fisiologia Clinica · ITAzienda Ospedaliera Universitaria Pisana · ITInstitute of Biostructure and Bioimaging · ITInstituto de Agroquímica y Tecnología de Alimentos · ESScuola Superiore Sant'Anna · ITUniversitat de València · ESUniversity of Pisa · IT

Funding

Italian Ministry of Agricultural, Food and Forestry Policies Ministry Decree 23092/7303/19Italian Ministry of Education, University and Research Ministry Decree no. 946/2019Ministry of Science and Innovation of Spain ACPIN2017-117Ministry of Science and Innovation of Spain PID2019-108973RB-C22
6 · The paper itself

Abstract

Metabolic impairments and liver and adipose depots alterations were reported in subjects with Alzheimer's disease (AD), highlighting the role of the liver-adipose-tissue-brain axis in AD pathophysiology. The gut microbiota might play a modulating role. We investigated the alterations to the liver and white/brown adipose tissues (W/BAT) and their relationships with serum and gut metabolites and gut bacteria in a 3xTg mouse model during AD onset (adulthood) and progression (aging) and the impact of high-fat diet (HFD) and intranasal insulin (INI). Glucose metabolism (

Indexed as

adipose tissuesAlzheimer’s disease mouse modelgut microbiotaliver inflammationmetabolomePET-CT imaging

Identifiers

PMID35448465
PMCPMC9028874
OpenAlexW4221122772

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.