Evidence map›Paper›PMID 35448452›Full record

ArticleToxics2022

Relationship of Blood and Urinary Manganese Levels with Cognitive Function in Elderly Individuals in the United States by Race/Ethnicity, NHANES 2011-2014.

Arturo J Barahona, Zoran Bursac, Emir Veledar, Roberto Lucchini, Kim Tieu, Jason R Richardson

Open access · goldAbstract read
In one paragraph

Article in Toxics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

  1. Association between blood manganese and cognitive function in a national representative survey.Journal of occupational medicine and toxicology (London, England) · 2026
    Article
  2. Article
  3. Arsenic, mercury, manganese, and lead exposure in Mexican adults aged 50 and older.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Metals in Alzheimer's Disease.Biomedicines · 2023
    Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Arturo J BarahonaDepartment of Environmental Health Sciences, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL 33199, USA.ORCID 0000-0001-5982-9516
Zoran BursacDepartment of Biostatistics, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL 33199, USA.
Emir VeledarDepartment of Biostatistics, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL 33199, USA.ORCID 0000-0002-3831-5433
Roberto LucchiniDepartment of Environmental Health Sciences, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL 33199, USA.ORCID 0000-0002-9723-0237
Kim TieuDepartment of Environmental Health Sciences, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL 33199, USA.
Jason R RichardsonDepartment of Environmental Health Sciences, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL 33199, USA.
Florida International University · US

Funding

The FIU Research Center in a Minority Institution (FIU-RCMI)U54MD012393 · NIMHD · FLORIDA INTERNATIONAL UNIVERSITY · PI Shanna L Burke · 2017 to 2026
$32.1M
Neurologic function in children exposed to ambient manganeseR01ES019222 · NIEHS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI Megan K Horton · 2010 to 2026
$9.1M
Toxicant-induced neurotoxicity mediated by glia-neuron and gene-environment interactions in Parkinson's diseaseR35ES030523 · NIEHS · FLORIDA INTERNATIONAL UNIVERSITY · PI KIM TIEU · 2019 to 2026
$6.7M
Mechanism of Gene Environment Interactions in Alzheimer's DiseaseR01ES026057 · NIEHS · NORTHEAST OHIO MEDICAL UNIVERSITY · PI RICHARDSON, JASON R · 2016 to 2020
$2.4M
Health Disparities in Alzheimers and Related DiseasesR13AG069380 · NIA · UNIVERSITY OF GEORGIA · PI RICHARDSON, JASON R · 2020 to 2024
$213k
NIEHS NIH HHS R35 ES030523NIEHS NIH HHS R35ES030523NIH HHS R01ES019222NIH HHS R01ES026057NIH HHS R13AG069380NIH HHS U54 MD012393
6 · The paper itself

Abstract

Manganese (Mn) is an essential metal with a biphasic relationship with health outcomes. High-level exposure to Mn is associated with manganism, but few data explore the effects of chronic, lower-level Mn on cognitive function in adults. We sought to determine the relationship between blood/urinary manganese levels and cognitive function in elderly individuals using 2011-2014 data from the National Health and Nutrition Examination Survey (NHANES). Weighted multivariate regression models were used to determine correlations, adjusting for several covariates. Blood Mn was inversely associated with the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) immediate learning of new verbal information (

Indexed as

Alzheimer’s diseaseanimal fluencyCERADcognitive functionDSSTenvironmental exposureethnicitymanganeseneurotoxicityrace

Identifiers

PMID35448452
PMCPMC9025725
OpenAlexW4224242963

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.