Evidence map›Paper›PMID 35448413›Full record

ArticleToxics2022

A Forensic Diagnostic Algorithm for Drug-Related Deaths: A Case Series.

Antonina Argo, Stefania Zerbo, Roberto Buscemi, Claudia Trignano, Elisabetta Bertol, Giuseppe Davide Albano, Fabio Vaiano

Open access · goldAbstract read
In one paragraph

Article in Toxics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. The Rise of Fentanyl: Molecular Aspects and Forensic Investigations.International journal of molecular sciences · 2025
    Review
  8. Article
  9. Challenges and insights: Methamphetamine analysis in post-mortem putrefied human tissues in a hot climate.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024
    Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Antonina ArgoPROMISE Department, University of Palermo, 90100 Palermo, Italy.ORCID 0000-0002-9964-0184
Stefania ZerboPROMISE Department, University of Palermo, 90100 Palermo, Italy.
Roberto BuscemiPROMISE Department, University of Palermo, 90100 Palermo, Italy.
Claudia TrignanoDepartment of Biomedical Sciences, University of Sassari, 7100 Sassari, Italy.ORCID 0000-0002-8846-0700
Elisabetta BertolDepartment of Health Sciences, University of Florence, 50121 Florence, Italy.
Giuseppe Davide AlbanoPROMISE Department, University of Palermo, 90100 Palermo, Italy.
Fabio VaianoDepartment of Health Sciences, University of Florence, 50121 Florence, Italy.ORCID 0000-0002-9256-4326
University of Palermo · ITUniversity of Florence · ITUniversity of Sassari · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The best evidence provided in the literature worldwide suggests the importance of harmonizing the investigation in drug-related fatalities. In this study, the application of a multidisciplinary approach in eight cases of drug-related deaths is presented. Although death scene findings could be highly suggestive of drug intoxication, external examination and toxicological screening test alone are insufficient. There are several variables, and it is not always easy to give the proper interpretation of the drug detection. A complete autopsy is necessary to correctly complete organ and tissues sampling for further histological and toxicological studies and obtain body fluids. The use of peripheral blood is recommended to avoid artifacts. The collection of many specimens is warranted to get more responses. The sampling aims to provide a picture of the distribution of the substance in the body. The sample and the selection of the drugs and the matrices to investigate are case-dependent. The presented diagnostic algorithm provides the coroner with all the elements to investigate drug-related deaths and cooperate with toxicologists. Toxicological forensic diagnosis is still extremely heterogeneous in regional and national contexts. Funding for method development, research, networking, facilities, and technologies improvement is mandatory to standardize the toxicological investigation.

Indexed as

diagnostic algorithmdrug intoxication diagnosisdrug-related deathsforensic diagnosis

Identifiers

PMID35448413
PMCPMC9024928
OpenAlexW4224313386

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.