Evidence map›Paper›PMID 35448368›Full record

ArticleMembranes2022

Electrospun Hybrid Films for Fast and Convenient Delivery of Active Herb Extracts.

Shiri Guo, Wenlai Jiang, Liangfei Shen, Gaoyi Zhang, Yiman Gao, Yaoyao Yang, Deng-Guang Yu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Membranes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shiri GuoSchool of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, China.
Wenlai JiangSchool of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, China.
Liangfei ShenSchool of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, China.
Gaoyi ZhangSchool of Optical-Electrical and Computer Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
Yiman GaoSchool of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, China.
Yaoyao YangSchool of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, China.
Deng-Guang YuSchool of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, China.ORCID 0000-0001-7825-4498

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herb medicines are popular for safe application due to being a source of natural herbs. However, how to deliver them in an efficacious and convenient manner poses a big challenge to researchers. In this study, a new concept is demonstrated that the electrospun polymer-based hybrid films can be a platform for promoting the delivery of a mixture of active herb extract, i.e., Lianhua Qingwen Keli (LQK), also a commercial traditional Chinese patent medicine. The LQK can be co-dissolved with the filament-forming polymeric polyvinylpyrrolidone K60 and a sweeter sucralose to prepare an electrospinnable solution. A handheld electrospinning apparatus was explored to transfer the solution into solid nanofibers, i.e., the LQK-loaded medicated films. These films were demonstrated to be composed of linear nanofibers. A puncher was utilized to transfer the mat into circular membrane a diameter of 15 mm. Two self-created methods were developed for disclosing the dissolution performances of the electrospun mats. Both the water droplet experiments and the wet paper (mimic tongue) experiments verified that the hybrid films can rapidly disintegrate when they encounter water and release the loaded LQK in an immediate manner. Based on the reasonable selections of polymeric excipients, the present protocols pave a way for delivering many types of active herb extracts in an effective and convenient manner.

Indexed as

drug deliveryelectrospinningfast dissolutionherb medicinehybrid filmmedicated film

Identifiers

PMID35448368
PMCPMC9031211

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.