ArticleBiosensors2022
An Eco-Friendly Synthetic Approach for Copper Nanoclusters and Their Potential in Lead Ions Sensing and Biological Applications.
Article in Biosensors, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 27 citations in OpenAlex.
- Phytosynthesized Silver Nanoparticles from Waste Kigelia africana Flowers: Characterization and Functional Applications.ChemistryOpen · 2026Article
- Recent Advances in Metal Nanoclusters: From Novel Synthesis to Emerging Applications.Molecules (Basel, Switzerland) · 2025Review
- Metal Nanocluster-Based Biosensors for DNA Detection.Biosensors · 2025Review
- Synthesis of Greenish-Yellow Fluorescent Copper Nanocluster for the Selective and Sensitive Detection of Fipronil Pesticide in Vegetables and Grain Samples.Journal of fluorescence · 2024Article
- Article
- Towards Green Synthesis of Fluorescent Metal Nanoclusters.Journal of fluorescence · 2023Review
- Advances in Ultra-small Fluorescence Nanoprobes for Detection of Metal Ions, Drugs, Pesticides and Biomarkers.Journal of fluorescence · 2023Review
- A Reversible Optical Sensor Film for Mercury Ions Discrimination Based on Isoxazolidine Derivative and Exhibiting pH Sensing.Biosensors · 2022Article
- Article
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
A new preparation route for high-luminescent blue-emission pepsin copper nanoclusters (Pep-CuNCs) is introduced in this work. The synthesized nanoclusters are based on a pepsin molecule, which is a stomach enzyme that works to digest proteins that exist in undigested food. Here, we have developed an eco-friendly technique through microwave-assisted fast synthesis. The resulting copper nanoclusters (CuNCs) exhibit significant selectivity towards Pb(II) ions. The pepsin molecule was utilized as a stabilizer and reducing agent in the production procedure of Pep-CuNCs. The characteristics of the resulting Pep-CuNCs were studied in terms of size, surface modification, and composition using various sophisticated techniques. The CuNCs responded to Pb(II) ions through the fluorescence quenching mechanism of the CuNCs' fluorescence. Thus, great selectivity of Pep-CuNCs towards Pb(II) ions was observed, allowing sensitive determination of this metal ion at lab-scale and in the environment. The CuNCs have detection limits for Pb(II) in very tenuous concentration at a nanomalar scale (11.54 nM). The resulting Pep-CuNCs were utilized significantly to detect Pb(II) ions in environmental samples. Additionally, the activity of Pep-CuNCs on different human tumor cell lines was investigated. The data for the observed behavior indicate that the Pep-CuNCs displayed their activity against cancer cells in a dose dependent manner against most utilized cancer cell lines.
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