Evidence map›Paper›PMID 35448163›Full record

ReviewCurrent oncology (Toronto, Ont.)2022

A Pleiotropic Role of Long Non-Coding RNAs in the Modulation of Wnt/β-Catenin and PI3K/Akt/mTOR Signaling Pathways in Esophageal Squamous Cell Carcinoma: Implication in Chemotherapeutic Drug Response.

Uttam Sharma, Masang Murmu, Tushar Singh Barwal, Hardeep Singh Tuli, Manju Jain, Hridayesh Prakash, Tea Kaceli, Aklank Jain, Anupam Bishayee

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current oncology (Toronto, Ont.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Clinical Significance ofDiseases (Basel, Switzerland) · 2025
    Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Epigenetic regulation of gastrointestinal cancers mediated by long non-coding RNAs.Cancer biomarkers : section A of Disease markers · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Uttam SharmaDepartment of Zoology, Central University of Punjab, Ghudda 151 401, Punjab, India.ORCID 0000-0001-5108-8872
Masang MurmuDepartment of Zoology, Central University of Punjab, Ghudda 151 401, Punjab, India.
Tushar Singh BarwalDepartment of Zoology, Central University of Punjab, Ghudda 151 401, Punjab, India.
Hardeep Singh TuliDepartment of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala 133 207, Haryana, India.ORCID 0000-0003-1155-0094
Manju JainDepartment of Biochemistry, Central University of Punjab, Ghudda 151 401, Punjab, India.
Hridayesh PrakashAmity Institute of Virology and Immunology, Amity University, Noida 201 301, Uttar Pradesh, India.ORCID 0000-0001-5269-2481
Tea KaceliCollege of Osteopathic Medicine, Lake Erie College of Osteopathic Medicine, Bradenton, FL 34211, USA.
Aklank JainDepartment of Zoology, Central University of Punjab, Ghudda 151 401, Punjab, India.ORCID 0000-0001-5539-3225
Anupam BishayeeCollege of Osteopathic Medicine, Lake Erie College of Osteopathic Medicine, Bradenton, FL 34211, USA.ORCID 0000-0001-9159-960X
Central University of Punjab · INLake Erie College of Osteopathic Medicine · USAmity University · INMaharishi Markandeshwar University, Mullana · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the availability of modern techniques for the treatment of esophageal squamous cell carcinoma (ESCC), tumor recurrence and metastasis are significant challenges in clinical management. Thus, ESCC possesses a poor prognosis and low five-year overall survival rate. Notably, the origin and recurrence of the cancer phenotype are under the control of complex cancer-related signaling pathways. In this review, we provide comprehensive knowledge about long non-coding RNAs (lncRNAs) related to Wnt/β-catenin and phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathway in ESCC and its implications in hindering the efficacy of chemotherapeutic drugs. We observed that a pool of lncRNAs, such as

Indexed as

Esophageal NeoplasmsEsophageal Squamous Cell CarcinomaRNA, Long Noncodingbeta CateninCell Line, TumorGene Expression Regulation, NeoplasticHumansNeoplasm Recurrence, LocalPhosphatidylinositol 3-KinasePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionTOR Serine-Threonine Kinasesbeta CateninMTOR protein, humanPhosphatidylinositol 3-KinasePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRNA, Long NoncodingTOR Serine-Threonine Kinaseschemotherapyesophageal squamous cell carcinomalong non-coding RNAsPI3K/Akt/mTORsignaling pathwaysWnt/β-catenin

Identifiers

PMID35448163
PMCPMC9031703
OpenAlexW4221054193

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.