Evidence map›Paper›PMID 35448064›Full record

ArticleDentistry journal2022

Salivary Scca1, Scca2 and Trop2 in Oral Cancer Patients-A Cross-Sectional Pilot Study.

Ivana Karmelić, Ivan Salarić, Ksenija Baždarić, Marko Rožman, Ivan Zajc, Marinka Mravak-Stipetić, Ivona Bago, Davor Brajdić, Jasna Lovrić, Darko Macan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Dentistry journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Ivana KarmelićDepartment of Medical Chemistry, Biochemistry and Clinical Chemistry, University of Zagreb School of Medicine, 10000 Zagreb, Croatia.ORCID 0000-0002-9611-6280
Ivan SalarićDepartment of Oral Surgery, University of Zagreb School of Dental Medicine, Av. Gojka Šuška 6, 10000 Zagreb, Croatia.
Ksenija BaždarićDepartment of Medical Informatics, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia.
Marko RožmanDepartment of Physical Chemistry, Ruđer Bošković Institute, 10000 Zagreb, Croatia.
Ivan ZajcDepartment of Medical Chemistry, Biochemistry and Clinical Chemistry, University of Zagreb School of Medicine, 10000 Zagreb, Croatia.
Marinka Mravak-StipetićDepartment of Oral Medicine, University of Zagreb School of Dental Medicine, 10000 Zagreb, Croatia.ORCID 0000-0001-8845-8603
Ivona BagoDepartment of Endodontics and Restorative Dentistry, University of Zagreb School of Dental Medicine, 10000 Zagreb, Croatia.ORCID 0000-0001-5938-4940
Davor BrajdićDepartment of Oral Surgery, University of Zagreb School of Dental Medicine, Av. Gojka Šuška 6, 10000 Zagreb, Croatia.
Jasna LovrićDepartment of Medical Chemistry, Biochemistry and Clinical Chemistry, University of Zagreb School of Medicine, 10000 Zagreb, Croatia.
Darko MacanDepartment of Oral Surgery, University of Zagreb School of Dental Medicine, Av. Gojka Šuška 6, 10000 Zagreb, Croatia.ORCID 0000-0001-8632-8186
University of Zagreb · HRRuđer Bošković Institute · HRUniversity of Rijeka · HR

Funding

Croatian Science Foundation IP-2014-9376
6 · The paper itself

Abstract

Oral squamous cell carcinoma (OSCC) is frequently diagnosed in the advanced stages. The purpose of this paper is to determine the salivary values of SCCA1, SCCA2 and TROP2 in patients with T1N0M0 OSCC and to compare them with the values obtained from healthy individuals. Unstimulated (UWS) and stimulated (SWS) saliva was sampled from 29 patients with T1N0M0 OSCC and 29 sex- and age-matched healthy individuals. Statistical difference was observed in SCCA1 and SCCA2 levels both in UWS and SWS samples. TROP2 was not measurable in most of the salivary samples. Both SCCA1 and SCCA2 could represent potential biomarkers for the early-stage OSCC. Research on a larger sample and biomarker validation is needed to assess the clinical potential of SCCA1 and SCCA2 in the OSCC early diagnostics.

Indexed as

biomarkersearly diagnosisoral cancersaliva

Identifiers

PMID35448064
PMCPMC9024948
OpenAlexW4224006205

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.