ArticleBrain sciences2022
Changes in the Intranetwork and Internetwork Connectivity of the Default Mode Network and Olfactory Network in Patients with COVID-19 and Olfactory Dysfunction.
Article in Brain sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- Functional brain abnormalities in post COVID-19 condition and their relationship with cognition.Scientific reports · 2025Trial
- Effects of hyperbaric oxygen therapy on functional and structural connectivity in post-COVID-19 condition patients: A randomized, sham-controlled trial.NeuroImage. Clinical · 2022Trial
- Brain connectivity and its relation to cognitive function in patients with post-COVID 19 condition after mild infection.Scientific reports · 2026Article
- Mapping the Olfactory Brain: A Systematic Review of Structural and Functional Magnetic Resonance Imaging Changes Following COVID-19 Smell Loss.Brain sciences · 2025Review
- Persistent dysfunctions of brain metabolic connectivity in long-covid with cognitive symptoms.European journal of nuclear medicine and molecular imaging · 2025Article
- Functional connectivity of default mode network in non-hospitalized patients with post-COVID cognitive complaints.Frontiers in neuroscience · 2025Article
- The effects of prolonged sitting behavior on resting-state brain functional connectivity in college students post-COVID-19 rehabilitation: A study based on fNIRS technology.Sports medicine and health science · 2024Article
- Patients recovering from COVID-19 who presented with anosmia during their acute episode have behavioral, functional, and structural brain alterations.Scientific reports · 2024Article
- Hippocampal Structures Among Japanese Adolescents Before and After the COVID-19 Pandemic.JAMA network open · 2024Article
- Microstructural brain abnormalities, fatigue, and cognitive dysfunction after mild COVID-19.Scientific reports · 2024Article
- Multimodal neuroimaging in Long-COVID and its correlates with cognition 1.8 years after SARS-CoV-2 infection: a cross-sectional study of theFrontiers in neurology · 2024Article
- Altered structural connectivity in olfactory disfunction after mild COVID-19 using probabilistic tractography.Scientific reports · 2023Article
- A Pilot Study of Short-Course Oral Vitamin A and Aerosolised Diffuser Olfactory Training for the Treatment of Smell Loss in Long COVID.Brain sciences · 2023Article
- Brain functional connectivity alterations associated with neuropsychological performance 6-9 months following SARS-CoV-2 infection.Human brain mapping · 2023Article
- Brain correlates of subjective cognitive complaints in COVID-19 survivors: A multimodal magnetic resonance imaging study.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2023Article
- Effects of post-acute COVID-19 syndrome on the functional brain networks of non-hospitalized individuals.Frontiers in neurology · 2023Article
- Correlations between Persistent Olfactory and Semantic Memory Disorders after SARS-CoV-2 Infection.Brain sciences · 2022Article
- Research progress and clinical application of functional magnetic resonance imaging in otolaryngology-head and neck diseases.Frontiers in neurologyReview
- Brain structural and functional damage network localization of COVID-19 survivors.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Olfactory dysfunction (OD) is a common symptom in coronavirus disease 2019 (COVID-19) patients. Moreover, many neurological manifestations have been reported in these patients, suggesting central nervous system involvement. The default mode network (DMN) is closely associated with olfactory processing. In this study, we investigated the internetwork and intranetwork connectivity of the DMN and the olfactory network (ON) in 13 healthy controls and 22 patients presenting with COVID-19-related OD using independent component analysis and region of interest functional magnetic resonance imaging (fMRI) analysis. There was a significant correlation between the butanol threshold test (BTT) and the intranetwork connectivity in ON. Meanwhile, the COVID-19 patients with OD showed significantly higher intranetwork connectivity in the DMN, as well as higher internetwork connectivity between ON and DMN. However, no significant difference was found between groups in the intranetwork connectivity within ON. We postulate that higher intranetwork functional connectivities compensate for the deficits in olfactory processing and general well-being in COVID-19 patients. Nevertheless, the compensation process in the ON may not be obvious at this stage. Our results suggest that resting-state fMRI is a potentially valuable tool to evaluate neurosensory dysfunction in COVID-19 patients.
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Registered trials
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