ReviewBrain sciences2022
The Concept of «Peritumoral Zone» in Diffuse Low-Grade Gliomas: Oncological and Functional Implications for a Connectome-Guided Therapeutic Attitude.
Review in Brain sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Progressive axonal degeneration in white matter pathways traversing peritumoral penumbra in frontotemporal glioma.Computational diffusion MRI. CDMRI (Workshop) · 2026Article
- Advances in the management of patients with IDH-mutant glioma.The oncologist · 2025Review
- Glioma Grading by Integrating Radiomic Features from Peritumoral Edema in Fused MRI Images and Automated Machine Learning.Journal of imaging · 2025Article
- Bi-Regional Machine Learning Radiomics Based on CT Noninvasively Predicts LOX Expression Level and Overall Survival in Hepatocellular Carcinoma.Cancer medicine · 2025Article
- Leveraging pathological markers of lower grade glioma to predict the occurrence of secondary epilepsy, a retrospective study.Scientific reports · 2025Article
- Survival prediction with radiomics for patients with IDH mutated lower-grade glioma.Journal of neuro-oncology · 2025Article
- Preoperative model for predicting early recurrence in hepatocellular carcinoma patients using radiomics and deep learning: A multicenter study.World journal of gastrointestinal oncology · 2025Article
- Gene mutations linked to drug-resistant epilepsy in astrocytoma.Frontiers in neurology · 2025Article
- Low expression of polo-like kinase 2 predicts high postoperative seizure recurrence in glioma-related epilepsy.American journal of translational research · 2025Article
- Intratumoral and peritumoral multiparametric MRI-based radiomics nomogram for preoperative risk stratification in patients with endometrial cancer.Frontiers in oncology · 2025Article
- The Alcatraz-Strategy: a roadmap to break the connectivity barrier in malignant brain tumours.Molecular oncology · 2024Review
- Gliomagenesis, Epileptogenesis, and Remodeling of Neural Circuits: Relevance for Novel Treatment Strategies in Low- and High-Grade Gliomas.International journal of molecular sciences · 2024Review
- Multiparametric simultaneous hybridQuantitative imaging in medicine and surgery · 2024Article
- Exploring prognostic factors and treatment strategies for long-term survival in pleomorphic xanthoastrocytoma patients.Scientific reports · 2024Article
- Value of intralesional and perilesional radiomics for predicting the bioactivity of hepatic alveolar echinococcosis.Frontiers in oncology · 2024Article
- Radiogenomics of adult intracranial gliomas after the 2021 World Health Organisation classification: a review of changes, challenges and opportunities.Quantitative imaging in medicine and surgery · 2023Review
- Seizure Management and Prophylaxis Considerations in Patients with Brain Tumors.Current oncology reports · 2023Review
- Editorial: Frontiers in Neuro Oncology and Neurosurgery.Brain sciences · 2023Article
- Preoperative validation of edema-corrected tractography in neurosurgical practice: translating surgeon insights into novel software implementation.Frontiers in neurology · 2023Article
- A Personalized Longitudinal Strategy in Low-Grade Glioma Patients: Predicting Oncological and Neural Interindividual Variability and Its Changes over Years to Think One Step Ahead.Journal of personalized medicine · 2022Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diffuse low-grade gliomas (DLGGs) are heterogeneous and poorly circumscribed neoplasms with isolated tumor cells that extend beyond the margins of the lesion depicted on MRI. Efforts to demarcate the glioma core from the surrounding healthy brain led us to define an intermediate region, the so-called peritumoral zone (PTZ). Although most studies about PTZ have been conducted on high-grade gliomas, the purpose here is to review the cellular, metabolic, and radiological characteristics of PTZ in the specific context of DLGG. A better delineation of PTZ, in which glioma cells and neural tissue strongly interact, may open new therapeutic avenues to optimize both functional and oncological results. First, a connectome-based "supratotal" surgical resection (i.e., with the removal of PTZ in addition to the tumor core) resulted in prolonged survival by limiting the risk of malignant transformation, while improving the quality of life, thanks to a better control of seizures. Second, the timing and order of (neo)adjuvant medical treatments can be modulated according to the pattern of peritumoral infiltration. Third, the development of new drugs specifically targeting the PTZ could be considered from an oncological (such as immunotherapy) and epileptological perspective. Further multimodal investigations of PTZ are needed to maximize long-term outcomes in DLGG patients.
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