Evidence map›Paper›PMID 35447892›Full record

ReviewMarine drugs2022

Biomaterials and Bioactive Natural Products from Marine Invertebrates: From Basic Research to Innovative Applications.

Giovanna Romano, Mariana Almeida, Ana Varela Coelho, Adele Cutignano, Luis G Gonçalves, Espen Hansen, Denis Khnykin, Tali Mass, Andreja Ramšak, Miguel S Rocha and 4 more

Open access · goldAbstract readReview
In one paragraph

Review in Marine drugs, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
12.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 101 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Building like a Coral-Parallelized, Multiscale Biofabrication.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
  5. Review
  6. Review
  7. Microorganisms · 2025
    Article
  8. Review
  9. Article
  10. Review
  11. Advancing marine invertebrate cell line research: four key knowledge gaps.In vitro cellular & developmental biology. Animal · 2025
    Review
  12. Immunomodulatory Effects ofAntioxidants (Basel, Switzerland) · 2025
    Article
  13. Review
  14. Article
  15. Cnidarian toxins: omics approaches and recombinant proteins.The journal of venomous animals and toxins including tropical diseases · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. The Promising Potential ofCurrent issues in molecular biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 10 institutions in 6 countries.

Giovanna RomanoMarine Biotechnology Department, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy.ORCID 0000-0002-4898-7153
Mariana Almeida3B's Research Group, I3B's-Research Institute on Biomaterials, Biodegradables and Biomimetics of University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark-Parque de Ciência e Tecnologia, Barco, 4805-017 Guimarães, Portugal.ORCID 0000-0002-0615-2318
Ana Varela CoelhoITQB NOVA, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Av. da República, 2780-157 Oeiras, Portugal.ORCID 0000-0002-6143-4203
Adele CutignanoMarine Biotechnology Department, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy.ORCID 0000-0003-3035-9252
Luis G GonçalvesITQB NOVA, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Av. da República, 2780-157 Oeiras, Portugal.
Espen HansenMarbio, UiT-The Arctic University of Norway, 9037 Tromso, Norway.ORCID 0000-0003-0354-986X
Denis KhnykinLaboratory for Immunohistochemistry and Immunopathology (LIIPAT), Department of Pathology, Oslo University Hospital-Rikshospitalet, 0450 Oslo, Norway.
Tali MassFaculty of Natural Science, Department of Marine Biology, Charney School of Marine Sciences, University of Haifa, Haifa 3498838, Israel.ORCID 0000-0002-7298-290X
Andreja RamšakNational Institute of Biology, Marine Biology Station, Fornače 41, SI-6330 Piran, Slovenia.
Miguel S Rocha3B's Research Group, I3B's-Research Institute on Biomaterials, Biodegradables and Biomimetics of University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark-Parque de Ciência e Tecnologia, Barco, 4805-017 Guimarães, Portugal.ORCID 0000-0002-0511-7174
Tiago H Silva3B's Research Group, I3B's-Research Institute on Biomaterials, Biodegradables and Biomimetics of University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark-Parque de Ciência e Tecnologia, Barco, 4805-017 Guimarães, Portugal.ORCID 0000-0001-8520-603X
Michela SugniDepartment of Environmental Science and Policy, University of Milan, Via Celoria, 2, 20133 Milan, Italy.ORCID 0000-0002-4574-5802
Loriano BallarinDepartment of Biology, University of Padova, Via U. Bassi 58/B, 35100 Padova, Italy.ORCID 0000-0002-3287-8550
Anne-Marie GenevièreBiologie Intégrative des Organismes Marins (BIOM), Observatoire Océanologique de Banyuls-sur-Mer, Sorbonne Université, CNRS, 1 Avenue Pierre Fabre, 66650 Banyuls-sur-Mer, France.
University of Minho · PTStazione Zoologica Anton Dohrn · ITUniversidade Nova de Lisboa · PTCentre National de la Recherche Scientifique · FRNational Institute of Biology · SIOslo University Hospital · NOUiT The Arctic University of Norway · NOUniversity of Haifa · ILUniversity of Milan · ITUniversity of Padua · IT

Funding

European Cooperation in Science and Technology 16203
6 · The paper itself

Abstract

Aquatic invertebrates are a major source of biomaterials and bioactive natural products that can find applications as pharmaceutics, nutraceutics, cosmetics, antibiotics, antifouling products and biomaterials. Symbiotic microorganisms are often the real producers of many secondary metabolites initially isolated from marine invertebrates; however, a certain number of them are actually synthesized by the macro-organisms. In this review, we analysed the literature of the years 2010-2019 on natural products (bioactive molecules and biomaterials) from the main phyla of marine invertebrates explored so far, including sponges, cnidarians, molluscs, echinoderms and ascidians, and present relevant examples of natural products of interest to public and private stakeholders. We also describe omics tools that have been more relevant in identifying and understanding mechanisms and processes underlying the biosynthesis of secondary metabolites in marine invertebrates. Since there is increasing attention on finding new solutions for a sustainable large-scale supply of bioactive compounds, we propose that a possible improvement in the biodiscovery pipeline might also come from the study and utilization of aquatic invertebrate stem cells.

Indexed as

Biological ProductsAnimalsAquatic OrganismsBiocompatible MaterialsEchinodermataInvertebratesMarine BiologyBiocompatible MaterialsBiological Productsbioactivitymarine biomaterialsmarine invertebratesmarine natural productsstem cells

Identifiers

PMID35447892
PMCPMC9027906
OpenAlexW4224321779

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.